Journal of Gastroenterology

, Volume 49, Issue 1, pp 73–80 | Cite as

The ability of a novel blue laser imaging system for the diagnosis of invasion depth of colorectal neoplasms

  • Naohisa YoshidaEmail author
  • Takashi Hisabe
  • Yutaka Inada
  • Munehiro Kugai
  • Nobuaki Yagi
  • Fumihito Hirai
  • Kenshi Yao
  • Toshiyuki Matsui
  • Akinori Iwashita
  • Mototsugu Kato
  • Akio Yanagisawa
  • Yuji Naito
Original Article—Alimentary Tract



Fujifilm has developed a novel endoscope system with two kinds of lasers that enables us to allow narrow-band light observation with blue laser imaging (BLI). The aim of this study was to evaluate BLI magnification in comparison with narrow-band imaging (NBI) magnification for the diagnosis of colorectal neoplasms.


This was a multicenter open study. A total of 104 colorectal neoplasms were examined with BLI and NBI magnifications in Kyoto Prefectural University of Medicine and Fukuoka University Chikushi Hospital. Vascular and surface patterns of tumors under BLI magnification were compared with those under NBI magnification, using a published NBI classification. The main outcome was the correlation between the NBI classification diagnosed by BLI or NBI magnification and the histopathological analyses.


Sixty-two cases of adenoma, 34 cases of intramucosal cancer and shallowly invaded submucosal cancer, and eight cases of deeply invaded submucosal cancer were diagnosed. The diagnostic accuracy of BLI magnification in the NBI classification was 74.0 % (77/104), similar to that of NBI magnification (77.8 %). The consistency rate between BLI and NBI magnification in the NBI classification was 74.0 %. Concerning image evaluation, the interobserver variability of two expert endoscopists (N.Y. and T.H.) in BLI magnification was κ = 0.863. On the other hand, the intraobserver variability of the two endoscopists was κ = 0.893 (N.Y.) and 0.851 (T.H.).


BLI magnification by laser source could predict histopathological diagnosis and invasion depth of colorectal neoplasms. The diagnostic effectiveness of this method was similar to that of NBI magnification.


BLI Laser NBI Colorectal polyps Image-enhanced endoscopy 



We thank all members of the Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, for helping with this study, and all members of the Department of Gastroenterology, Fukuoka University Chikushi Hospital. We thank Dr. Hironori Yamamoto for making the study design. We also thank Kubo Masahiro and all other members who assisted in all procedures related to the Fujifilm LASEREO system.

Conflict of interest

The Fujifilm Co. contributed to the BLI system in this study for free. Besides this, none of the authors have any conflict of interest or financial support to declare.


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Copyright information

© Springer Japan 2013

Authors and Affiliations

  • Naohisa Yoshida
    • 1
    Email author
  • Takashi Hisabe
    • 2
  • Yutaka Inada
    • 1
  • Munehiro Kugai
    • 1
  • Nobuaki Yagi
    • 1
  • Fumihito Hirai
    • 2
  • Kenshi Yao
    • 2
  • Toshiyuki Matsui
    • 2
  • Akinori Iwashita
    • 3
  • Mototsugu Kato
    • 4
  • Akio Yanagisawa
    • 5
  • Yuji Naito
    • 1
  1. 1.Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyotoJapan
  2. 2.Department of GastroenterologyFukuoka University Chikushi HospitalFukuokaJapan
  3. 3.Department of PathologyFukuoka University Chikushi HospitalFukuokaJapan
  4. 4.Department of EndoscopyHokkaido University HospitalHokkaidoJapan
  5. 5.Department of Surgical Pathology, Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyotoJapan

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