Journal of Gastroenterology

, Volume 48, Issue 7, pp 822–829

A bioabsorbable polymer patch for the treatment of esophageal defect in a porcine model

  • Masayasu Aikawa
  • Mitsuo Miyazawa
  • Kojun Okamoto
  • Katsuya Okada
  • Naoe Akimoto
  • Hiroshi Sato
  • Isamu Koyama
  • Shigeki Yamaguchi
  • Yoshito Ikada
Original Article—Alimentary Tract

Abstract

Background

Although several materials have been used to replace the esophagus, none of the materials appears to be feasible for clinical use. Our group has developed a bioabsorbable polymer that can be used to repair the defects of stomach, small intestine, biliary tract, and veins. In this study, we implanted a bioabsorbable polymer patch (BAPP) into an esophageal defect and we investigated the clinical utility of BAPP and evaluated the process of esophageal regeneration.

Methods

Pigs (n = 9) underwent right thoracotomy under general anesthesia. A 4 × 2-cm oval-shaped portion of the esophageal wall was excised, and a BAPP was implanted at the excision site. Esophageal endoscopy was performed at 2 weeks after the implantation. At 4, 8, and 12 weeks after implantation, the whole esophagus was resected for gross and histological examinations of the graft sites.

Result

Esophageal endoscopy at 2 weeks revealed a tiny ulceration at the implantation site with no stenosis. At 4 weeks, the epithelium at the graft site was similar to that of the native esophagus, but it lacked a proper muscle layer. At 8 weeks, a rough muscle layer had developed. At 12 weeks, normal mucosa and a proper muscle layer similar to that of the native wall were confirmed.

Conclusion

BAPP repaired the defective esophageal wall without complications, and a neo esophageal wall identical to the native esophageal wall had formed by 12 weeks after implantation. Hence, this newly designed substitute has the potential for application as a novel treatment for defective esophagus.

Keywords

Bioabsorbable material Tissue engineering Esophageal defect Esophageal reconstruction 

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Copyright information

© Springer Japan 2012

Authors and Affiliations

  • Masayasu Aikawa
    • 1
  • Mitsuo Miyazawa
    • 1
  • Kojun Okamoto
    • 1
  • Katsuya Okada
    • 1
  • Naoe Akimoto
    • 1
  • Hiroshi Sato
    • 1
  • Isamu Koyama
    • 1
  • Shigeki Yamaguchi
    • 1
  • Yoshito Ikada
    • 2
  1. 1.Department of Surgery, Gastrointestinal CenterSaitama Medical University, International Medical CenterHidakaJapan
  2. 2.Division of Life ScienceNara Medical UniversityNaraJapan

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