Journal of Gastroenterology

, Volume 48, Issue 6, pp 706–712 | Cite as

Risk factors for lymphatic and venous involvement in endoscopically resected gastric cancer

  • Masau Sekiguchi
  • Shigeki SekineEmail author
  • Ichiro Oda
  • Satoru Nonaka
  • Haruhisa Suzuki
  • Shigetaka Yoshinaga
  • Hirokazu Taniguchi
  • Hitoshi Tsuda
  • Ryoji Kushima
  • Yutaka Saito
Original Article—Alimentary Tract



Lymphatic and venous involvement is a critical factor in the curability assessment of endoscopically resected gastric cancers; however, the risk factors for lymphatic and venous involvement in endoscopically resected gastric cancers remain unknown.


To identify risk factors for lymphatic and venous involvement in endoscopically resected gastric cancers, we retrospectively reviewed a consecutive series of 1229 endoscopically resected gastric cancers in 1083 patients treated between January 2009 and December 2011.


Lymphatic and venous involvement was detected in 57 (4.6 %) and 32 (2.6 %) lesions, respectively. A multivariate analysis identified a larger tumor size, deeper invasion (submucosal invasion or deeper), and the presence of a papillary or an undifferentiated-type adenocarcinoma component as independent risk factors for lymphatic involvement. As for venous involvement, deeper invasion (≥500 μm submucosal invasion), a macroscopically elevated type, and the presence of an undifferentiated-type adenocarcinoma component were identified as independent risk factors.


The present study identified the independent risk factors for lymphatic and venous involvement in endoscopically resected gastric cancers. The recognition of these risk factors would help in the selection of lesions that may require a particularly careful histological evaluation.


Gastric cancer Endoscopic resection Papillary adenocarcinoma Undifferentiated-type adenocarcinoma Lymphatic involvement Venous involvement 


Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Japan 2012

Authors and Affiliations

  • Masau Sekiguchi
    • 1
  • Shigeki Sekine
    • 2
    Email author
  • Ichiro Oda
    • 1
  • Satoru Nonaka
    • 1
  • Haruhisa Suzuki
    • 1
  • Shigetaka Yoshinaga
    • 1
  • Hirokazu Taniguchi
    • 3
  • Hitoshi Tsuda
    • 3
  • Ryoji Kushima
    • 3
  • Yutaka Saito
    • 1
  1. 1.Endoscopy DivisionNational Cancer Center HospitalTokyoJapan
  2. 2.Molecular Pathology DivisionNational Cancer Center Research InstituteTokyoJapan
  3. 3.Pathology DivisionNational Cancer Center HospitalTokyoJapan

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