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Journal of Gastroenterology

, Volume 46, Issue 12, pp 1382–1390 | Cite as

Quantitative analysis of colorectal lesions observed on magnified endoscopy images

  • Keiichi Onji
  • Shigeto YoshidaEmail author
  • Shinji Tanaka
  • Rie Kawase
  • Yoshito Takemura
  • Shiro Oka
  • Toru Tamaki
  • Bisser Raytchev
  • Kazufumi Kaneda
  • Masaharu Yoshihara
  • Kazuaki Chayama
Original Article—Alimentary Tract

Abstract

Background

Various surface mucosal pit patterns, as recognized by endoscopists, correlate with the histologic features of colorectal cancers. We investigated whether magnified endoscopy images of these pit patterns could be analyzed quantitatively and thus facilitate computer-aided diagnosis of colorectal lesions.

Methods

We applied both texture analysis and scale-invariant feature transform (SIFT) descriptors and discriminant analysis to magnified endoscopy images of 165 neoplastic colorectal lesions (pit patterns: type IIIL/IV, n = 44; type VI-mildly irregular, n = 36; type VI-severely irregular, n = 45; type VN, n = 40) [histologic findings: tubular adenoma (TA), n = 56; carcinoma with intramucosal or even scant submucosal invasion (M/SM-s), n = 52, carcinoma with massive submucosal invasion (SM-m), n = 57]. We analyzed differences in pit pattern values and corresponding histologic values to determine whether the values were diagnostically meaningful.

Results

Gray-level difference matrix (GLDM) inverse difference moment and spatial gray-level dependence matrix (SGLDM) local homogeneity values differed significantly between type IIIL/IV and type VN pit patterns. Values differed significantly for each analyzed feature between type IIIL/IV and type VI-severely irregular patterns and were high but descending for type IIIL/IV, type VI-mildly irregular, and type VI-severely irregular pit patterns (in that order). Similarly, texture analysis yielded high but descending values for TA, M/SM-s, and SM-m (in that order). Furthermore, SIFT descriptors and discriminant analysis yielded differences that were superior to those obtained by texture analyses.

Conclusions

Computer analysis of magnified endoscopy images for the diagnosis of colorectal lesions appears feasible. We anticipate further developments in the computer-aided diagnosis of pit patterns on magnified endoscopy images.

Keywords

Magnifying chromoendoscopy Quantitative analysis Image analysis Colon cancer Colonoscopy 

Notes

Acknowledgments

We would like to thank Jyunki Yoshimuta for his work with the calculation of images.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer 2011

Authors and Affiliations

  • Keiichi Onji
    • 1
  • Shigeto Yoshida
    • 2
    Email author
  • Shinji Tanaka
    • 2
  • Rie Kawase
    • 1
  • Yoshito Takemura
    • 1
  • Shiro Oka
    • 2
  • Toru Tamaki
    • 3
  • Bisser Raytchev
    • 3
  • Kazufumi Kaneda
    • 3
  • Masaharu Yoshihara
    • 4
  • Kazuaki Chayama
    • 1
  1. 1.Department of Medicine and Molecular Science, Graduate School of Biomedical SciencesHiroshima UniversityHiroshimaJapan
  2. 2.Department of EndoscopyHiroshima University HospitalHiroshimaJapan
  3. 3.Department of Information Engineering, Graduate School of EngineeringHiroshima UniversityHiroshimaJapan
  4. 4.Department of Health Service CenterHiroshima UniversityHiroshimaJapan

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