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Journal of Gastroenterology

, Volume 46, Issue 11, pp 1260–1266 | Cite as

Genetic variation in PLCE1 is associated with gastric cancer survival in a Chinese population

  • Dewei Luo
  • Yan Gao
  • Shizhi Wang
  • Meilin Wang
  • Dongmei Wu
  • Wei Wang
  • Ming Xu
  • Jianwei Zhou
  • Weida Gong
  • Yongfei Tan
  • Zhengdong ZhangEmail author
Original Article—Alimentary Tract

Abstract

Background

Two genome-wide association studies on gastric cancer showed a previously unknown gastric cancer susceptible locus in PLCE1 at 10q23. We hypothesized that the single nucleotide polymorphism (SNP) rs2274223 A/G is associated with the survival rate of gastric cancer.

Methods

We genotyped the above SNP in 940 gastric cancer patients to investigate the association between the polymorphism and gastric cancer survival by the TaqMan method.

Results

We found that patients carrying PLCE1 rs2274223 AA genotype survived for a significantly shorter time than those carrying the AG and GG genotypes (log-rank P = 0.046). This significance was enhanced in the dominant model (AA vs. AG/GG, log-rank P = 0.014). Multivariate Cox regression analyses showed that the AG/GG genotypes were associated with a significantly decreased risk of death from gastric cancer [adjusted hazard ratio (HR) = 0.79, 95% confidence interval (CI) = 0.65–0.95]. Most of stratification analysis did not find an enhanced association between the same genotype and prognosis, except for patients with TNM stage III disease (HR = 0.63, 95% CI = 0.48–0.83).

Conclusion

Our findings showed that the PLCE1 SNP rs2274223 was associated with significantly improved gastric cancer survival in a Chinese population. Further functional studies are needed to validate our results.

Keywords

PLCE1 GWAS Gastric cancer Polymorphism Survival 

Notes

Acknowledgments

This study was partly supported by the National Natural Science Foundation of China (30872084 and 30972444), the National Natural Science Foundation of Jiangsu Province (2010080), the Key Program for Basic Research of Jiangsu Provincial Department of Education (08KJA330001), the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), and the Postdoctoral Science Foundation of China (20100481164).

Conflict of interest

The authors declare no conflicts of interest.

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Copyright information

© Springer 2011

Authors and Affiliations

  • Dewei Luo
    • 1
  • Yan Gao
    • 1
  • Shizhi Wang
    • 1
  • Meilin Wang
    • 2
  • Dongmei Wu
    • 2
  • Wei Wang
    • 1
  • Ming Xu
    • 1
  • Jianwei Zhou
    • 3
  • Weida Gong
    • 4
  • Yongfei Tan
    • 5
  • Zhengdong Zhang
    • 1
    • 2
    Email author
  1. 1.Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public HealthNanjing Medical UniversityNanjingChina
  2. 2.Department of Occupational Medicine and Environmental Health, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public HealthNanjing Medical UniversityNanjingChina
  3. 3.Department of Molecular Cell Biology and Toxicology, School of Public Health, Cancer CenterNanjing Medical UniversityNanjingChina
  4. 4.Department of General SurgeryYixing Cancer HospitalYixingChina
  5. 5.Department of General SurgeryYixing People’s HospitalYixingChina

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