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Journal of Gastroenterology

, 46:1142 | Cite as

Eosinophilic esophagitis investigated by upper gastrointestinal endoscopy in Japanese patients

  • Hirofumi Fujishiro
  • Yuji Amano
  • Yoshinori Kushiyama
  • Shunji Ishihara
  • Yoshikazu Kinoshita
Rapid Communication

Abstract

Background

The prevalence of eosinophilic esophagitis (EE) is increasing rapidly in Western countries. Several case series of EE have also been reported in Japan. However, the prevalence of EE in Japanese patients as investigated by upper gastrointestinal endoscopy is unknown. Therefore, we carried out a prospective multicenter study to address this issue.

Methods

From July to December 2010, 23,346 patients who had undergone routine upper gastrointestinal endoscopy in 17 institutions were enrolled. In patients with symptoms suggesting EE, such as dysphasia, food impaction, and heartburn, and/or in patients in whom endoscopic findings suggested pathology, esophageal biopsy samples were collected, and the numbers of eosinophils in the squamous epithelium were counted.

Results

During the study period of 6 months, 4 patients were endoscopically and histologically diagnosed with EE. The prevalence of EE was calculated to be 17.1/100,000.

Conclusion

The prevalence of EE in Japanese patients by upper gastrointestinal endoscopy has now been documented.

Keywords

Eosinophilic esophagitis Prevalence Japanese population 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Dobbins JW, Sheahan DG, Behar J. Eosinophilic gastroenteritis with esophageal involvement. Gastroenterology. 1977;72:1312–6.PubMedGoogle Scholar
  2. 2.
    Furuta GT, Liacouras CA, Collins MH, Gupta SK, Justinich C, Putnam PE, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007;133:1342–63.PubMedCrossRefGoogle Scholar
  3. 3.
    Straumann A, Simon HU. Eosinophilic esophagitis: escalating epidemiology? J Allergy Clin Immunol. 2005;115:418–9.PubMedCrossRefGoogle Scholar
  4. 4.
    Prasad GA, Alexander JA, Schleck CD, Zinsmeister AR, Smyrk TC, Elias RM, et al. Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota. Clin Gastroenterol Hepatol. 2009;7:1055–61.PubMedCrossRefGoogle Scholar
  5. 5.
    Furuta K, Adachi K, Kowari K, Mishima Y, Imaoka H, Kadota C, et al. A Japanese case of eosinophilic esophagitis. J Gastroenterol. 2006;41:706–10.PubMedCrossRefGoogle Scholar
  6. 6.
    Sano H, Iwakiri K, Kawami N, Tnaka Y, Umezawa M, Iizumi T, et al. Eosinophilic esophagitis: a case report with a review of the literature. Clin J Gastroenterol. 2010;3:279–84.CrossRefGoogle Scholar
  7. 7.
    Abe Y, Iijima K, Ohara S, Koike T, Ara N, Uno K, et al. A Japanese case series of 12 patients with esophageal eosinophilia. J Gastroenterol. 2011;46:25–30.PubMedCrossRefGoogle Scholar
  8. 8.
    Veerappan GR, Perry JL, Duncan TJ, Baker TP, Maydonovitch C, Lake JM, et al. Prevalence of eosinophilic esophagitis in an adult population undergoing upper endoscopy: a prospective study. Clin Gastroenterol Hepatol. 2009;7:420–6.PubMedCrossRefGoogle Scholar
  9. 9.
    Remedios M, Campbell C, Jones DM, Kerlin P. Eosinophilic esophagitis in adults: clinical, endoscopic, histologic findings, and response to treatment with fluticasone propionate. Gastrointest Endosc. 2006;63:3–12.PubMedCrossRefGoogle Scholar
  10. 10.
    Müller S, Pühl S, Vieth M, Stolte M. Analysis of symptoms and endoscopic findings in 117 patients with histological diagnoses of eosinophilic esophagitis. Endoscopy. 2007;39:339–44.PubMedCrossRefGoogle Scholar
  11. 11.
    Mishra A, Hogan SP, Brandt EB, Rothenberg ME. An etiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest. 2001;107:83–90.PubMedCrossRefGoogle Scholar
  12. 12.
    Spergel JM, Beausoleil JL, Mascarenhas M, Liacouras CA. The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis. J Allergy Clin Immunol. 2002;109:363–8.PubMedCrossRefGoogle Scholar
  13. 13.
    Molina-Infante J, Ferrando-Lamana L, Ripoll C, Hernandez-Alonso M, Mateos JM, Fernandez-Bermejo M, et al. Esophageal eosinophilic infiltration responds to proton pump inhibition in most adults. Clin Gastroenterol Hepatol. 2011;9:110–7.PubMedCrossRefGoogle Scholar
  14. 14.
    Dranove JE, Horn DS, Davis MA, Kernek KM, Gupta SK. Predictors of response to proton pump inhibitor therapy among children with significant esophageal eosinophilia. J Pediatr. 2009;154:96–100.PubMedCrossRefGoogle Scholar
  15. 15.
    Peterson KA, Thomas KL, Hilden K, Emerson LL, Wills JC, Fang JC. Comparison of esomeprazole to aerosolized, swallowed fluticasone for eosinophilic esophagitis. Dig Dis Sci. 2010;55:1313–9.PubMedCrossRefGoogle Scholar
  16. 16.
    Dellon ES, Aderoju A, Woosley JT, Sandler RS, Shaheen NJ. Variability in diagnostic criteria for eosinophilic esophagitis: a systematic review. Am J Gastroenterol. 2007;102:2300–13.PubMedCrossRefGoogle Scholar
  17. 17.
    Paterson WG. Role of mast cell-derived mediators in acid-induced shortening of the esophagus. Am J Physiol. 1998;274:G385–8.PubMedGoogle Scholar
  18. 18.
    Kottyan LC, Collier AR, Cao KH, Niese KA, Hedgebeth M, Radu CG, et al. Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner. Blood. 2009;114:2774–82.PubMedGoogle Scholar
  19. 19.
    Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, et al. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol. 2010;184:4033–41.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2011

Authors and Affiliations

  • Hirofumi Fujishiro
    • 1
  • Yuji Amano
    • 2
  • Yoshinori Kushiyama
    • 3
  • Shunji Ishihara
    • 4
  • Yoshikazu Kinoshita
    • 4
  1. 1.Division of EndoscopyShimane Prefectural Central HospitalIzumoJapan
  2. 2.Division of EndoscopyShimane University HospitalIzumoJapan
  3. 3.Division of GastroenterologyMatsue Red Cross HospitalMatsueJapan
  4. 4.Second Department of Internal MedicineShimane University, Faculty of MedicineIzumoJapan

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