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Journal of Gastroenterology

, Volume 46, Issue 7, pp 938–943 | Cite as

Liver functional volumetry for portal vein embolization using a newly developed 99mTc-galactosyl human serum albumin scintigraphy SPECT–computed tomography fusion system

  • Toru Beppu
  • Hiromitsu Hayashi
  • Hirohisa Okabe
  • Toshiro Masuda
  • Kosuke Mima
  • Ryu Otao
  • Akira Chikamoto
  • Koichi Doi
  • Takatoshi Ishiko
  • Hiroshi Takamori
  • Morikatsu Yoshida
  • Shinya Shiraishi
  • Yasuyuki Yamashita
  • Hideo Baba
Original Article—Liver, Pancreas, and Biliary Tract

Abstract

Background

We developed a new combined 99mTc-galactosyl human serum albumin (GSA) scintigraphy single-photon emission computed tomography (SPECT)/CT system to evaluate the changes in functional liver volume with portal vein embolization (PVE).

Methods

We performed a prospective analysis of 25 patients treated with right PVE, and evaluated their functional liver volume perioperatively with a 99mTc-GSA scintigraphy SPECT–CT fusion system. The percentage of the non-tumorous remnant liver volume (%LV) and the percentage of functional remnant liver volume (%FLV) were estimated by using the following calculations: (future remnant volume − tumor volume)/(total liver volume − tumor volume) and functional future remnant liver volume/functional total liver volume, respectively.

Results

Before PVE, the correlation was strongly significant between %LV and %FLV of the non-embolized liver, and the data were nearly equal (the regression coefficient was 1.005, P < 0.0001). In contrast, after PVE, there was a significant correlation between %LV and %FLV (P < 0.0001), but the regression coefficient was 1.192. The % LV increased significantly, from 38.1 to 52.0%, and the increment was 13.9% (P < 0.0005). The %FLV was also increased significantly, from 36.6 to 58.0%, and the increment was 21.4% (P < 0.0001). The increment was 7.5% greater for the %FLV compared to that of the %LV (P < 0.001).

Conclusions

The 99mTc-GSA scintigraphy SPECT–CT fusion system can estimate the correct functional liver volume and is useful in comparison with conventional CT volumetry.

Keywords

Portal vein embolization 99mTc-Galactosyl human serum albumin scintigraphy SPECT–computed tomography fusion system Functional liver volume 

Abbreviations

HCC

Hepatocellular carcinoma

PVE

Portal vein embolization

%LV

Percentage of non-tumorous remnant liver volume

%FLV

Percentage of functional remnant liver volume

SPECT

Single-photon emission computed tomography

99mTc-GSA scintigraphy

99mTc-galactosyl human serum albumin scintigraphy

LHL 15

Uptake ratio of the liver to the liver plus heart at 15 min

ICG R15

Indocyanine green retention rate at 15 min

Notes

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer 2011

Authors and Affiliations

  • Toru Beppu
    • 1
  • Hiromitsu Hayashi
    • 1
  • Hirohisa Okabe
    • 1
  • Toshiro Masuda
    • 1
  • Kosuke Mima
    • 1
  • Ryu Otao
    • 1
  • Akira Chikamoto
    • 1
  • Koichi Doi
    • 1
  • Takatoshi Ishiko
    • 1
  • Hiroshi Takamori
    • 1
  • Morikatsu Yoshida
    • 2
  • Shinya Shiraishi
    • 2
  • Yasuyuki Yamashita
    • 2
  • Hideo Baba
    • 1
  1. 1.Department of Gastroenterological SurgeryGraduate School of Medical Sciences, Kumamoto UniversityKumamotoJapan
  2. 2.Department of Diagnostic RadiologyGraduate School of Medical Sciences, Kumamoto UniversityKumamotoJapan

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