Journal of Gastroenterology

, Volume 46, Issue 7, pp 913–920

The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus

  • Shohei Komatsu
  • Takumi Fukumoto
  • Yusuke Demizu
  • Daisuke Miyawaki
  • Kazuki Terashima
  • Yasue Niwa
  • Masayuki Mima
  • Osamu Fujii
  • Ryohei Sasaki
  • Isamu Yamada
  • Yuichi Hori
  • Yoshio Hishikawa
  • Mitsuyuki Abe
  • Yonson Ku
  • Masao Murakami
Original Article—Liver, Pancreas, and Biliary Tract

Abstract

Background

The prognosis of patients who have hepatocellular carcinoma (HCC) associated with inferior vena cava tumor thrombus (IVCTT) is very poor, and effective treatment modalities are extremely limited. The objective of this study was to determine the therapeutic efficacy of particle radiotherapy for HCC with IVCTT.

Methods

Between June 2001 and January 2009, 16 evaluable patients who had HCC with IVCTT were treated with particle radiotherapy. They were divided into 2 groups: 6 were treated with curative intent; 10 with palliative intent. The local tumor control rates, overall survival rates, and toxicities were evaluated.

Results

All tumors treated with particle radiotherapy remained controlled without local recurrence at the last follow-up. The overall survival rates for the 16 patients at 1 and 3 years were 61.1 and 36.7%, respectively. We observed a significant difference in the survival rates according to treatment policy. The median survival time was 25.4 months for patients treated with curative intent and 7.7 months for those treated with palliative intent. The one-year survival rates were 100.0 and 33.3%, respectively. No Grade 3 or higher treatment-related toxicities were observed.

Conclusions

Particle radiotherapy is thought to be potentially effective and safe for HCC with IVCTT. Considering the current lack of effective and less-invasive local therapy for HCC with IVCTT, particle radiotherapy may therefore be an attractive new therapeutic approach for this type of HCC.

Keywords

Hepatocellular carcinoma Inferior vena cava tumor thrombus Proton radiotherapy Carbon ion radiotherapy Particle radiotherapy 

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Copyright information

© Springer 2011

Authors and Affiliations

  • Shohei Komatsu
    • 1
  • Takumi Fukumoto
    • 1
  • Yusuke Demizu
    • 2
  • Daisuke Miyawaki
    • 3
  • Kazuki Terashima
    • 2
  • Yasue Niwa
    • 2
  • Masayuki Mima
    • 2
  • Osamu Fujii
    • 2
  • Ryohei Sasaki
    • 3
  • Isamu Yamada
    • 1
  • Yuichi Hori
    • 1
  • Yoshio Hishikawa
    • 2
  • Mitsuyuki Abe
    • 2
  • Yonson Ku
    • 1
  • Masao Murakami
    • 2
  1. 1.Division of Hepato-Biliary-Pancreatic Surgery, Department of SurgeryKobe University Graduate School of MedicineKobeJapan
  2. 2.Department of RadiologyHyogo Ion Beam Medical CenterTatsunoJapan
  3. 3.Division of Radiation Oncology, Department of RadiologyKobe University Graduate School of MedicineKobeJapan

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