Journal of Gastroenterology

, Volume 46, Issue 6, pp 769–778

Impact of cigarette smoking on onset of nonalcoholic fatty liver disease over a 10-year period

  • Ayaka Hamabe
  • Hirofumi Uto
  • Yasushi Imamura
  • Ken Kusano
  • Seiichi Mawatari
  • Kotaro Kumagai
  • Takeshi Kure
  • Tsutomu Tamai
  • Akihiro Moriuchi
  • Toshio Sakiyama
  • Makoto Oketani
  • Akio Ido
  • Hirohito Tsubouchi
Original Article—Liver, Pancreas, and Biliary Tract

DOI: 10.1007/s00535-011-0376-z

Cite this article as:
Hamabe, A., Uto, H., Imamura, Y. et al. J Gastroenterol (2011) 46: 769. doi:10.1007/s00535-011-0376-z

Abstract

Background

Metabolic syndrome, which includes obesity, hyperglycemia, dyslipidemia, and hypertension, is a major risk factor for the development of nonalcoholic fatty liver disease (NAFLD). Cigarette smoking is a well-known risk factor for metabolic syndrome, but the epidemiological impact of cigarette smoking on development of NAFLD is unclear.

Methods

In this retrospective study, 2,029 subjects underwent a complete medical health checkup in 1998 and again in 2008. Those who were positive for hepatitis B surface antigen or hepatitis C virus antibody, or had an alcohol intake of >20 g/day as assessed by questionnaire, were excluded. Fatty liver was diagnosed by abdominal ultrasonography. Independent risk factors associated with the development of NAFLD were determined by multiple logistic regression analysis. Smoking status was expressed using the Brinkman index (BI), which was calculated as the number of cigarettes smoked per day multiplied by the number of years of smoking.

Results

Of 1,560 subjects without NAFLD in 1998, 266 (17.1%) were newly diagnosed with NAFLD in 2008. Multiple logistic analysis identified age [adjusted odds ratio (AOR) 0.95, 95% confidence interval (95% CI) 0.94–0.97], male sex (AOR 1.46, 95% CI 1.01–2.10), body mass index ≥25 (AOR 3.08, 95% CI 2.20–4.32), dyslipidemia (AOR 1.79, 95% CI 1.25–2.58) and cigarette smoking (AOR 1.91, 95% CI 1.34–2.72) as risk factors associated with the development of NAFLD. Smoking status at baseline was also associated with the development of NAFLD (BI 1–399: AOR 1.77, 95% CI 1.02–3.07, BI ≥400: AOR 2.04, 95% CI 1.37–3.03).

Conclusion

Cigarette smoking is an independent risk factor for onset of NAFLD.

Keywords

NAFLD Risk factor Brinkman index Body mass index Metabolic syndrome 

Copyright information

© Springer 2011

Authors and Affiliations

  • Ayaka Hamabe
    • 1
  • Hirofumi Uto
    • 1
  • Yasushi Imamura
    • 2
  • Ken Kusano
    • 3
  • Seiichi Mawatari
    • 1
  • Kotaro Kumagai
    • 1
  • Takeshi Kure
    • 1
  • Tsutomu Tamai
    • 1
  • Akihiro Moriuchi
    • 1
  • Toshio Sakiyama
    • 1
  • Makoto Oketani
    • 1
  • Akio Ido
    • 1
  • Hirohito Tsubouchi
    • 1
  1. 1.Department of Digestive and Life-Style Related Diseases, Health Research Human and Environmental SciencesKagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan
  2. 2.Department of Internal MedicineKagoshima Kouseiren HospitalKagoshimaJapan
  3. 3.Kagoshima Kouseiren Medical Health Care CenterKagoshimaJapan

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