Journal of Gastroenterology

, Volume 46, Issue 3, pp 359–366 | Cite as

A novel transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma: a prospective randomized trial

  • Takahiro YamasakiEmail author
  • Satoe Hamabe
  • Issei Saeki
  • Yohei Harima
  • Yuhki Yamaguchi
  • Koichi Uchida
  • Shuji Terai
  • Isao Sakaida
Original Article—Liver, Pancreas, and Biliary Tract



We designed a novel transcatheter arterial infusion chemotherapy (TAI) using iodized oil (lipiodol) and degradable starch microspheres (DSM) for hepatocellular carcinoma (HCC) patients. In this study, we investigated the efficacy of TAI using lipiodol and DSM in a prospective randomized trial.


We randomly divided 45 patients with HCC into 3 groups: TAI using lipiodol (lipiodol group, n = 15), TAI using DSM (DSM group, n = 15), and TAI using lipiodol and DSM (lipiodol + DSM group, n = 15). In the lipiodol group, a mixture of cisplatin and lipiodol was administered. In the DSM group, a mixture of cisplatin and DSM was administered. In the lipiodol + DSM group, a mixture of cisplatin and lipiodol was administered, followed by DSM.


The response rates were 40% in the lipiodol group, 53.4% in the DSM group, and 80% in the lipiodol + DSM group, respectively. The response rate tended to improve in the lipiodol + DSM group (lipiodol group vs. lipiodol + DSM group, P = 0.07). The median progression-free survival time was 177 days in the lipiodol group, 287 days in the DSM group, and 377 days in the lipiodol + DSM group. The progression-free survival in the lipiodol + DSM group was significantly better than those in the DSM group (P = 0.020) and the lipiodol group (P = 0.035). There were no serious adverse effects among the 3 groups.


TAI using lipiodol and DSM was superior to TAI using lipiodol only and TAI using DSM only because of improvements in therapeutic effects and progression-free survival.


Hepatocellular carcinoma Transcatheter arterial infusion chemotherapy Iodized oil Degradable starch microspheres Randomized trial 



This study was supported by a grant-in-aid for scientific research from the Japan Society for the Promotion of Science (Grant No. 20591478).


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Copyright information

© Springer 2010

Authors and Affiliations

  • Takahiro Yamasaki
    • 1
    Email author
  • Satoe Hamabe
    • 1
  • Issei Saeki
    • 1
  • Yohei Harima
    • 1
  • Yuhki Yamaguchi
    • 1
  • Koichi Uchida
    • 1
  • Shuji Terai
    • 1
  • Isao Sakaida
    • 1
  1. 1.Department of Gastroenterology and HepatologyYamaguchi University Graduate School of MedicineUbeJapan

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