Journal of Gastroenterology

, Volume 45, Issue 1, pp 86–94 | Cite as

Etiology of liver cirrhosis in Japan: a nationwide survey

  • Kojiro Michitaka
  • Shuhei Nishiguchi
  • Yutaka Aoyagi
  • Yoichi Hiasa
  • Yoshio Tokumoto
  • Morikazu Onji
  • The Japan Etiology of Liver Cirrhosis Study Group
Original Article—Liver, Pancreas, and Biliary Tract

Abstract

Background

Little is understood about worldwide changes in the epidemiological distribution of the etiology of liver cirrhosis (LC). The present study examines the etiology of liver cirrhosis in Japan using a nationwide survey.

Methods

We analyzed data from 33,379 patients with LC at 58 hospitals and presented the findings in a poster symposium regarding the etiology and clinical features of LC in Japan that was included in the program of the 44th Annual Meeting of the Japan Society of Hepatology. We identified the distribution of the etiology of LC and compared the present with previous Japanese findings to estimate the future of etiological changes in LC.

Results

The etiological agents were as follows: hepatitis B virus (HBV) 13.9%, hepatitis C virus (HCV) 60.9%, alcohol 13.6%, primary biliary cirrhosis (PBC) 2.4% and autoimmune hepatitis (AIH) 1.9%. Cirrhosis was considered to be related to nonalcoholic steatohepatitis (NASH) in 2.1% of the patients. The ratio of HCV-related LC was significantly higher among patients with hepatocellular carcinoma (HCC) (P < 0.0001) compared to those without, whereas the ratios of alcohol, PBC, AIH were lower. HCC was evident in 31.5% of NASH-related LC.

Conclusions

The major etiology of liver cirrhosis in Japan remains HCV. Our survey revealed the prevalence of NASH-related LC in Japan and the frequency of HCC. Future changes in etiology must be considered in establishing preventive or educational strategies, as well as in developing new treatment strategies.

Keywords

Carcinogenesis Hepatitis B virus Hepatitis C virus Hepatocellular carcinoma Nonalcoholic steatohepatitis 

Abbreviations

AIH

Autoimmune hepatitis

ANA

Anti-nuclear antibody

BMI

Body mass index

DM

Diabetes mellitus

HBV

Hepatitis B virus

HCC

Hepatocellular carcinoma

HCV

Hepatitis C virus

LC

Liver cirrhosis

MetS

Metabolic syndrome

NAFLD

Nonalcoholic fatty liver disease

NASH

Nonalcoholic steatohepatitis

PBC

Primary biliary cirrhosis

PSC

Primary sclerosing cholangitis

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Copyright information

© Springer 2009

Authors and Affiliations

  • Kojiro Michitaka
    • 1
  • Shuhei Nishiguchi
    • 2
  • Yutaka Aoyagi
    • 3
  • Yoichi Hiasa
    • 1
  • Yoshio Tokumoto
    • 1
  • Morikazu Onji
    • 1
  • The Japan Etiology of Liver Cirrhosis Study Group
  1. 1.Department of Gastroenterology and MetabologyEhime University Graduate School of MedicineToonJapan
  2. 2.Division of Hepatobiliary and Pancreatic Disease, Department of Internal MedicineHyogo College of MedicineNishinomiyaJapan
  3. 3.Division of Gastroenterology and HepatologyGraduate School of Medical and Dental Sciences of Niigata UniversityNiigataJapan

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