Journal of Gastroenterology

, Volume 44, Issue 7, pp 675–684 | Cite as

Short-term and long-term outcome of endoluminal gastroplication for the treatment of GERD: the first multicenter trial in Japan

  • Soji OzawaEmail author
  • Koichiro Kumai
  • Kazuhide Higuchi
  • Tetsuo Arakawa
  • Mototsugu Kato
  • Masahiro Asaka
  • Natsuya Katada
  • Hiroyuki Kuwano
  • Masaki Kitajima
Original Article—Alimentary Tract



Endoluminal gastroplication (ELGP) was the first endoscopic therapy for gastroesophageal reflux disease (GERD). Data on the long-term outcomes, including the plication status and data from Asian populations, are limited. The aim of this study was to evaluate the short-term and long-term effectiveness and safety of ELGP for GERD in the Japanese population.


This was an open-label, prospective, multicenter trial of ELGP. Forty-eight patients with GERD were enrolled. The procedure involved placing circumferential plications 1–2 cm below the GE junction using the EndoCinch system. Outcome measurements were improvement of heartburn, medication use, endoscopic Los Angeles grade, durability of plications, 24-h esophageal acid exposure, esophageal manometry, and frequency of adverse events.


During the 24-month follow-up, the rate of complete resolution of heartburn ranged from 54 to 66%, the rate of discontinuation or reduction of PPI/H2RA use ranged from 65 to 76%, and the rate of endoscopic classification to grade O ranged from 66 to 81%. The status with more than one plication remaining was associated with higher rates of improvement of heartburn, PPI/H2RA use, and endoscopic findings as compared with those associated with the loss of all plications. A modest decrease of the esophageal acid exposure level, but no change of the manometric parameters, was observed after ELGP. No serious adverse events were observed.


In this 24-month follow-up study conducted in Japanese subjects, ELGP was found to be effective in about 60% of patients with GERD, and the procedure was safe.





The authors thank Professor Shuji Hashimoto, Department of Hygiene, School of Medicine, Fujita Health University, for his invaluable help with the statistical analysis.


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Copyright information

© Springer 2009

Authors and Affiliations

  • Soji Ozawa
    • 1
    Email author
  • Koichiro Kumai
    • 2
  • Kazuhide Higuchi
    • 3
  • Tetsuo Arakawa
    • 4
  • Mototsugu Kato
    • 5
  • Masahiro Asaka
    • 6
  • Natsuya Katada
    • 7
  • Hiroyuki Kuwano
    • 8
  • Masaki Kitajima
    • 9
  1. 1.Department of General and Gastrointestinal Surgery, School of MedicineFujita Health UniversityNagoyaJapan
  2. 2.Department of SurgeryHino Municipal HospitalHinoJapan
  3. 3.2nd Department of Internal MedicineOsaka Medical CollegeTakatsukiJapan
  4. 4.Department of GastroenterologyOsaka City University Graduate School of MedicineOsakaJapan
  5. 5.Division of EndoscopyHokkaido University HospitalSapporoJapan
  6. 6.Department of Gastroenterology and HematologyHokkaido University Graduate School of MedicineSapporoJapan
  7. 7.Department of Surgery, School of MedicineKitasato UniversitySagamiharaJapan
  8. 8.Department of General Surgical ScienceGunma University Graduate School of MedicineMaebashiJapan
  9. 9.Department of SurgeryInternational University of Health and Welfare Mita HospitalTokyoJapan

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