The loss of HBeAg without precore mutation results in lower HBV DNA levels and ALT levels in chronic hepatitis B virus infection

  • Naoto Kawabe
  • Senju Hashimoto
  • Masao Harata
  • Yoshifumi Nitta
  • Michihito Murao
  • Takuji Nakano
  • Hiroaki Shimazaki
  • Yuko Arima
  • Naruomi Komura
  • Kyoko Kobayashi
  • Kentaro Yoshioka
Original Article—Liver, Pancreas, and Biliary Tract

DOI: 10.1007/s00535-009-0061-7

Cite this article as:
Kawabe, N., Hashimoto, S., Harata, M. et al. J Gastroenterol (2009) 44: 751. doi:10.1007/s00535-009-0061-7

Abstract

Background

The aim of this study was to investigate the correlation between precore (PC)/basal core promoter (BCP) mutations and the viral loads or activity of hepatitis in patients with chronic hepatitis B virus (HBV) infection.

Methods

HBV genotypes, PC mutations, BCP mutations, HBV DNA levels, and serological markers of HBV were analyzed in all the patients with chronic HBV infection seen in Fujita Health University Hospital from June 2004 to November 2008 (n = 215).

Results

HBV genotype was C in 169 patients, B in 16, A in 3, F in 1, and unclassifiable in 5. Among the patients with genotype C, the prevalence of PC wild type was significantly lower in hepatitis B envelope antigen (HBeAg)(−) patients than in HBeAg(+) patients (9.5% versus 49.0%, P < 0.0001). Among HBeAg(−) patients, the patients with PC wild type had significantly lower serum viral loads and alanine aminotransferase (ALT) levels compared with those with PC mutant (P < 0.001). Among HBeAg(−) patients, the patients with genotype B had lower serum viral loads compared with those with genotype C (3.6 ± 0.9 versus 4.6 ± 1.6, P < 0.05), and the prevalence of BCP wild type was significantly higher in those with genotype B than in those with genotype C (58.3% versus 10.8%, P < 0.05).

Conclusions

Among HBeAg(−) patients with genotype C, the patients with PC wild type had significantly lower viral loads and ALT levels than those with PC mutant. This suggests that the patients with PC wild type may have better prognosis than those with PC mutant among HBeAg(−) patients with genotype C.

Keywords

Precore mutation Basal core promoter mutation Hepatitis B virus HBV genotype 

Copyright information

© Springer 2009

Authors and Affiliations

  • Naoto Kawabe
    • 1
  • Senju Hashimoto
    • 1
  • Masao Harata
    • 1
  • Yoshifumi Nitta
    • 1
  • Michihito Murao
    • 1
  • Takuji Nakano
    • 1
  • Hiroaki Shimazaki
    • 1
  • Yuko Arima
    • 1
  • Naruomi Komura
    • 1
  • Kyoko Kobayashi
    • 1
  • Kentaro Yoshioka
    • 1
  1. 1.Division of Liver, Biliary Tract and Pancreas Diseases, Department of Internal MedicineFujita Health UniversityToyoakeJapan

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