Journal of Gastroenterology

, Volume 44, Issue 5, pp 365–371 | Cite as

Clinical prevention of gastric cancer by Helicobacter pylori eradication therapy: a systematic review

  • Masanori ItoEmail author
  • Shunsuke Takata
  • Masana Tatsugami
  • Yoshihiro Wada
  • Shinobu Imagawa
  • Yoshiaki Matsumoto
  • Akemi Takamura
  • Shosuke Kitamura
  • Taiji Matsuo
  • Shinji Tanaka
  • Ken Haruma
  • Kazuaki Chayama


Helicobacter pylori (H. pylori) infection plays an important role in gastric carcinogenesis. We conducted a systematic review concerning gastric cancer development after H. pylori eradication therapy. In total 15 papers matched our criteria, the results were reviewed. The H. pylori eradication therapy statistically diminished the prevalence of clinical gastric cancer by approximately one-third. The studies from Japan supported this conclusion; however, studies from overseas reported conflicting results. The differences in these conclusions lie in the diagnostic ability of endoscopic examination, since the clinical stage was quite different between these studies. Gastric cancer that developed after eradication revealed a mainly intestinal type histology and depressed-type appearance. The following are possible reasons for reduced gastric cancer: (1) eradication therapy inhibits the new occurrence of gastric cancer, (2) eradication regresses or inhibits the growth of gastric cancer, and (3) eradication interferes with the discovery of gastric cancer. Considering the biological nature of cancer cell proliferation, a sufficiently long-term follow-up may clarify the effect of eradication therapy on inhibition of the development (not discovery) of gastric cancer and reduction of gastric cancer-related mortality.


H. pylori Eradication Gastritis Gastric cancer Systematic review 


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Copyright information

© Springer 2009

Authors and Affiliations

  • Masanori Ito
    • 1
    Email author
  • Shunsuke Takata
    • 1
  • Masana Tatsugami
    • 1
  • Yoshihiro Wada
    • 1
  • Shinobu Imagawa
    • 1
  • Yoshiaki Matsumoto
    • 1
  • Akemi Takamura
    • 1
  • Shosuke Kitamura
    • 1
  • Taiji Matsuo
    • 1
  • Shinji Tanaka
    • 2
  • Ken Haruma
    • 3
  • Kazuaki Chayama
    • 1
  1. 1.Department of Medicine and Molecular ScienceHiroshima UniversityHiroshimaJapan
  2. 2.Department of EndoscopyHiroshima University HospitalHiroshimaJapan
  3. 3.Gastroenterology Unit, Department of Internal MedicineKawasaki Medical SchoolKurashikiJapan

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