Functional dyspepsia: past, present, and future
- 391 Downloads
Functional dyspepsia (FD) is a highly prevalent gastrointestinal disorder characterized by symptoms originating from the gastroduodenal region in the absence of underlying organic disease that readily explains the symptoms. The Rome II consensus, which defined FD as the presence of unexplained pain or discomfort in the epigastrium, had a number of drawbacks, including an unjustified focus on pain, inclusion of a large number of nonspecific symptoms, and an unclear position on overlap with gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS). The Rome III consensus redefined FD as the presence of epigastric pain or burning, postprandial fullness or early satiation in the absence of underlying organic disease. Frequent overlap with GERD and IBS is acknowledged but does not exclude a diagnosis of FD. A subgroup classification into postprandial distress syndrome and epigastric pain syndrome was proposed. Ongoing studies will clarify the impact of this subdivision on clinical management and treatment outcomes.
Key wordsRome III consensus postprandial distress syndrome (PDS) epigastric pain syndrome (EPS) postprandial fullness early satiation
Unable to display preview. Download preview PDF.
- 2.Colin-Jones DG, Bloom B, Bodemar G, Crean G, Freston J, Gugler R, et al. Management of dyspepsia: report of a working party. Lancet 1988;1:576–579.Google Scholar
- 4.Talley NJ, Koch KL, Koch M, et al. Functional dyspepsia: a classification with guidelines for diagnosis and management. Gastrointest Int 1991;4:145–160.Google Scholar
- 5.Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, Tytgat GNJ. Functional gastroduodenal disorders. Gut 1999;45(Suppl) II:37–42.Google Scholar
- 13.Tack J, Talley NJ, Coulie B, Dubois D, Jones M. Association of weight loss with gastrointestinal symptoms in a tertiary-referred patient population. Gastroenterology 2003 (abstract).Google Scholar
- 14.Jones M, Talley N, Coulie B, Dubois J, Tack J. Association of weight loss with gastrointestinal symptoms. Gastroenterology 2003 (abstract).Google Scholar
- 17.Camilleri M, Dubois D, Coulie B, Jones M, Stewart WF, Sonnenberg A, et al. Results from the US upper gastrointestinal study: prevalence, socio-economic impact and functional gastrointestinal disorder subgroups identified by factor and cluster analysis. Clin Gastroenterol Hepatol 2005;3:543–552.CrossRefPubMedGoogle Scholar
- 18.Piessevaux H, De Winter B, Louis E, Muls V, De Looze D, Pelckmans P, et al. Dyspeptic symptoms in the general population: a factor and cluster analysis of symptom groupings. 2008 (submitted).Google Scholar