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Journal of Gastroenterology

, Volume 42, Issue 9, pp 761–768 | Cite as

Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma

  • Zhi Yong Gao
  • Tong Li
  • Jia Wang
  • Ji Mei Du
  • Ya Juan Li
  • Jie Li
  • Feng Min Lu
  • Hui Zhuang
Liver, Pancreas, and Biliary Tract

Abstract

Background

Hepatitis B virus (HBV) preS mutations are frequently isolated from patients with severe forms of liver disease. Meanwhile, genotype C has been shown to cause more serious liver disease than genotype B. This study assesses the frequency of preS mutation in Chinese patients with genotype C chronic HBV infection and its relation to liver damage.

Methods

Seventy-nine persistently infected patients (25 asymptomatic carriers, 28 with chronic hepatitis, and 26 with hepatocellular carcinoma) with genotype C HBV were analyzed. Levels of HBV DNA, hepatitis B e antigen (HBeAg), alanine aminotransferase, and aspartate transaminase and mutations in the preS region were determined.

Results

The correlations of preS deletion with disease progression were distinct: preS deletion mutations were more commonly found in the hepatocellular carcinoma (HCC) group than in the chronic hepatitis B (CHB) or asymptomatic carrier (ASC) groups, with the frequencies of 38.46% (10/26) in the HCC, 7.14% (2/28) in the CHB, and 4.00% (1/25) in the ASC (P = 0.001) groups. The HBeAg-positive rate and HBV DNA levels were comparable between patients with the preS mutation and those without.

Conclusions

PreS deletion mutations of genotype C HBV might play a role in HBV-related hepatocarcinogenesis.

Key words

hepatitis B virus (HBV) genotype C preS mutation hepatocellular carcinoma (HCC) 

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Copyright information

© Springer-Verlag Tokyo 2007

Authors and Affiliations

  • Zhi Yong Gao
    • 1
  • Tong Li
    • 1
  • Jia Wang
    • 1
  • Ji Mei Du
    • 2
  • Ya Juan Li
    • 1
  • Jie Li
    • 1
  • Feng Min Lu
    • 1
  • Hui Zhuang
    • 1
  1. 1.Department of MicrobiologyPeking University Health Science CenterBeijingChina
  2. 2.School of Laboratory MedicineWenzhou Medical CollegeWenzhouChina

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