Stress maladjustment in the pathoetiology of ulcerative colitis
- First Online:
- 126 Downloads
The aims of this study were (1) to measure levels of cytokines and stress hormones in ulcerative colitis (UC) patients and determine whether there were any disturbances in the nervous, endocrine, or immune systems, and (2) to measure the ability of UC patients to cope with stress (using a sense of coherence, SOC, test) and their perceived self-efficacy, and to elucidate their response to a stress load.
We administered questionnaires to and took blood samples from 42 outpatients and eight inpatients whose UC was in remission, and 21 healthy volunteers. In addition, we evaluated blood samples from the inpatients and healthy volunteers following a mental calculation stress test.
The questionnaire results revealed that self-efficacy was significantly decreased in the patient groups. Levels of adrenocorticotropic hormone, β-endorphin and interleukin (IL)-6 were significantly higher in the outpatient than in the control group. IL-6 levels significantly increased following the mental calculation stress test in UC patients compared with in the volunteers.
These results indicate that UC patients (1) have hypersensitive nervous, endocrine, and immune systems, and (2) this hypersensitivity was augmented by the mental calculation stress test.
Key wordscytokines hypothalamic–pituitary–adrenal axis mental calculation stress test self-efficacy stress hormone
Unable to display preview. Download preview PDF.
- 6.Kresse, AE, Million, M, Saperas, E, Tache, Y 2001Colitis induces CRF expression in hypothalamic magnocellular neurons and blunts CRF gene response to stress in ratsAm J Physiol Gastrointest Liver Physiol281G1023213Google Scholar
- 9.Sherer, M, Maddux, J, Mercandante, B, Prentice-Dunn, S, Jacobs, B, Rogers, RW 1982The self-efficacy scale: construction and validationPsychol Rep5166371Google Scholar
- 10.Sakano, Y, Tohjoh, M 1986The general self-efficacy scale (GSES): scale development and validation (in Japanese with English abstract)Jpn J Behav Ther127382Google Scholar
- 13.Togari, T, Yamazaki, Y 2005Examination of the reliability and factor validity of 13-item five-point version sense of coherence scale (in Japanese with English abstract)Minzoku Eisei7116882Google Scholar
- 14.Iwahashi, S, Tanaka, Y, Fukudo, S, Hongo, M 2002The development of the Japanese version of the perceived stress scale (in Japanese with English abstract)Jpn J Psychosom Med4245966Google Scholar
- 18.Kmiec, Z 1998Cytokines in inflammatory bowel diseaseArch Immunol Ther Exp (Warsz)4614355Google Scholar