Journal of Gastroenterology

, Volume 42, Issue 2, pp 181–185 | Cite as

A case of lymphoepithelioma-like carcinoma of the colon with ulcerative colitis

  • Yasuyuki Kojima
  • Masatoshi Mogaki
  • Ryo Takagawa
  • Ikuko Ota
  • Mitsutaka Sugita
  • Shiho Natori
  • Yohei Hamaguchi
  • Haruki Kurosawa
  • Tadao Fukushima
  • Hidenobu Masui
  • Shingo Fukazawa
  • Shoji Yamanaka
  • Yukio Tsuura
  • Kaoru Nagahori
Case report

Abstract

Follow-up colonoscopy of a 25-year-old Japanese man with ulcerative colitis (UC) who had undergone endoscopic mucosal resection twice for early colon cancers revealed the presence of a new 1.5-cm-diameter tumor in the sigmoid colon. It was diagnosed by preoperative biopsy as a poorly differentiated adenocarcinoma. Sigmoidectomy was performed, and the pathological findings revealed lymphoepithelioma-like carcinoma (LEC). In situ hybridization to detect Epstein-Barr virus (EBV)-encoded small RNAs showed positive signals in stromal lymphocytes, but weak signals in the tumor cells. The association between EBV and LEC was obscure in this case. Unlike typical UC-mediated colon cancers, the lesion was poorly differentiated, and negative for p53 signals immunohistochemically. These findings may hint at a novel mechanism of carcinogenesis in UC-mediated colorectal cancer.

Key words

lymphoepithelioma-like carcinoma UC EBV 

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Copyright information

© Springer-Verlag Tokyo 2007

Authors and Affiliations

  • Yasuyuki Kojima
    • 1
  • Masatoshi Mogaki
    • 1
  • Ryo Takagawa
    • 1
  • Ikuko Ota
    • 1
  • Mitsutaka Sugita
    • 1
  • Shiho Natori
    • 1
  • Yohei Hamaguchi
    • 1
  • Haruki Kurosawa
    • 1
  • Tadao Fukushima
    • 1
  • Hidenobu Masui
    • 1
  • Shingo Fukazawa
    • 1
  • Shoji Yamanaka
    • 2
  • Yukio Tsuura
    • 2
  • Kaoru Nagahori
    • 1
  1. 1.Department of SurgeryYokosuka Kyosai HospitalKanagawaJapan
  2. 2.Department of PathologyYokosuka Kyosai HospitalKanagawaJapan

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