Journal of Gastroenterology

, Volume 42, Issue 1, pp 39–48

Valproic acid-induced pancreatitis: 16 new cases and a review of the literature

  • Thorsten Gerstner
  • Deike Büsing
  • Nellie Bell
  • Elke Longin
  • Johannes-Martin Kasper
  • Wolfgang Klostermann
  • Burkhard Hebing
  • Folker Hanefeld
  • Ulrich Eckel
  • Reiner Hoffmann
  • Ulrich Bettendorf
  • Birgit Weidner
  • Adelheid Wiemer-Kruel
  • Knut Brockmann
  • Fritz-Wilhelm Neumann
  • Thorsten Sandrieser
  • Markus Wolff
  • Stephan König
Article

DOI: 10.1007/s00535-006-1961-4

Cite this article as:
Gerstner, T., Büsing, D., Bell, N. et al. J Gastroenterol (2007) 42: 39. doi:10.1007/s00535-006-1961-4

Abstract

Background

Acute pancreatitis is rarely seen in children, and, in contrast to cases in adults, it is often drug induced. One possible medication is the antiepileptic drug valproic acid (VPA), which is commonly prescribed for generalized and focal epilepsy, migraine, neuropathic pain, and bipolar disorder. The common side effects associated with VPA are typically benign, but less common but more serious adverse effects may occur. These include hepatotoxicity, hyperammonemic encephalopathy, coagulation disorders, and pancreatitis. Since 1979, a few cases of pancreatitis induced by VPA have been published in the medical literature.

Methods

We mailed a questionnaire to all members of the “German Section of the International League against Epilepsy,” asking about VPA-induced side effects. We also reviewed the medical literature for VPA-induced pancreatitis.

Results

Fifty-three publications (90 patients) published from 1979 to 2005 were found. Our survey in Germany, however, yielded 16 cases of pancreatitis from 1994 to 2003 whose original files we could study in detail. None of these patients had been published previously.

Conclusions

The difference between 90 patients reported worldwide from 1979 to 2005 and the 16 new documented cases from only Germany over 10 years corroborates that the occurrence of this severe side effect is under reported.

Key words

valproate pancreatitis lipase outcome 

Copyright information

© Springer-Verlag Tokyo 2007

Authors and Affiliations

  • Thorsten Gerstner
    • 1
  • Deike Büsing
    • 1
  • Nellie Bell
    • 1
  • Elke Longin
    • 1
  • Johannes-Martin Kasper
    • 2
  • Wolfgang Klostermann
    • 3
  • Burkhard Hebing
    • 4
  • Folker Hanefeld
    • 5
  • Ulrich Eckel
    • 6
  • Reiner Hoffmann
    • 7
  • Ulrich Bettendorf
    • 8
  • Birgit Weidner
    • 9
  • Adelheid Wiemer-Kruel
    • 10
  • Knut Brockmann
    • 5
  • Fritz-Wilhelm Neumann
    • 11
  • Thorsten Sandrieser
    • 12
  • Markus Wolff
    • 13
  • Stephan König
    • 1
  1. 1.University Children’s Hospital MannheimNeuropediatric UnitMannheimGermany
  2. 2.Wartburg-Klinikum EisenachGermany
  3. 3.HagenGermany
  4. 4.DetmoldGermany
  5. 5.Georg-August UniversityGöttingenGermany
  6. 6.Osterholz-ScharmbeckGermany
  7. 7.General HospitalOffenburgGermany
  8. 8.HirschaidGermany
  9. 9.Children’s HospitalCottbusGermany
  10. 10.Kehl-KorkGermany
  11. 11.Children’s HospitalErfurtGermany
  12. 12.Kemperhof HospitalKoblenzGermany
  13. 13.University Children’s HospitalTübingenGermany

Personalised recommendations