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Journal of Gastroenterology

, Volume 41, Issue 7, pp 647–653 | Cite as

Helicobacter pylori eradication versus prokinetics in the treatment of functional dyspepsia: a randomized, double-blind study

  • Tiing Leong Ang
  • Kwong Ming Fock
  • Eng Kiong Teo
  • Yiong Huak Chan
  • Tay Meng Ng
  • Tju Siang Chua
  • Jessica Yi-Lyn Tan
Article

Abstract

Background

This randomized, double-blind study compared the efficacy of Helicobacter pylori eradication against prokinetics in H. pylori-infected functional dyspepsia patients.

Methods

Patients with moderately severe or severe dyspepsia fulfilling the Rome II criteria were randomized to either H. pylori eradication for 1 week and 6 weeks of placebo prokinetics or 6 weeks of prokinetics and placebo H. pylori eradication in the first week. Symptoms were assessed at baseline and at 6 and 12 months using the Glasgow Dyspepsia Severity Score (GDSS). Global response to treatment was assessed at 12 months.

Results

Altogether 130 patients were enrolled (H. pylori eradication, 71; prokinetics, 59). The mean baseline GDSS was 9.3 for the H. pylori eradication group and 8.9 for the prokinetic group. At 6 months, the score was 3.6 and 4.1, respectively, and it remained at 3.5 and 3.8, respectively, at 12 months. With H. pylori eradication, 31.0% had complete symptom resolution (GDSS 0 or 1) at 12 months compared with 23.7% with prokinetics (a nonsignificant difference). At 12 months, global symptomatic improvement was seen in 62.0% of the H. pylori eradication group compared with 67.8% of the prokinetics group.

Conclusions

Both H. pylori eradication and prokinetic therapy resulted in symptom improvement in two-thirds of dyspeptic patients at 1 year. More patients tended to achieve complete symptom relief with H. pylori eradication.

Key words

H. pylori eradication prokinetics functional dyspepsia 

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Copyright information

© Springer-Verlag Tokyo 2006

Authors and Affiliations

  • Tiing Leong Ang
    • 1
  • Kwong Ming Fock
    • 1
  • Eng Kiong Teo
    • 1
  • Yiong Huak Chan
    • 2
  • Tay Meng Ng
    • 1
  • Tju Siang Chua
    • 1
  • Jessica Yi-Lyn Tan
    • 1
  1. 1.Department of GastroenterologyChangi General HospitalSingaporeSingapore
  2. 2.Department of Biostatistics, Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore

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