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Journal of Gastroenterology

, Volume 40, Issue 11, pp 1061–1064 | Cite as

Plasma total homocysteine and gallstone in middle-aged Japanese men

  • Hidenari Sakuta
  • Takashi Suzuki
Article

Abstract

Background

We wished to determine whether selected coronary risk factors correlated with the presence of gallstone (GS) in middle-aged Japanese men.

Methods

We carried out a cross-sectional study of 974 male Self-Defense officials. The odds ratio of a 1-SD increment in levels of coronary risk factors for the presence of GS was calculated in a logistic regression analysis.

Results

Nine subjects had undergone cholecystectomy. Gallstone was detected in 39 subjects and not in 926 subjects. The presence of GS was associated with total homocysteine (tHcy), but not with total cholesterol, triglyceride, γ-glutamyl transferase, glucose, or folate. The odds ratio of a 2.8-µmol/l increase (1 SD) in tHcy levels for the presence of GS was 1.34 (95% confidence interval [CI], 1.05–1.69; P = 0.017), and the ratio was 1.33 (95% CI, 1.04–1.70; P = 0.025) after being adjusted for lifestyle factors, including cigarette smoking, vegetable intake, physical activity, and abstention from alcohol.

Conclusions

Plasma tHcy, but not the other coronary risk factors, correlated with the presence of GS in middle-aged Japanese men. This association may partly explain the reported high prevalence rate of coronary heart disease in subjects with GS.

Key words

gallstone homocysteine oxidative stress smoking vegetable 

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References

  1. 1.
    Bortnichak, EA, Freeman, DH,Jr, Ostfeld, AM, Castelli, WP, Kannel, WB, Feinleib, M,  et al. 1985The association between cholesterol cholelithiasis and coronary heart diseases in Framingham, MassachusettsAm J Epidemiol1211930PubMedGoogle Scholar
  2. 2.
    Dickerman, JL 1991Gallbladder disease and coronary artery disease: is there a link?J Am Osteopath Assoc9135961PubMedGoogle Scholar
  3. 3.
    Misciagna, G, Centonze, S, Leoci, C, Guerra, V, Cisternino, AM, Ceo, R,  et al. 1999Diet, physical activity, and gallstones—a population-based, case-control study in southern ItalyAm J Clin Nutr691206PubMedGoogle Scholar
  4. 4.
    Devesa, F, Ferrando, J, Caldentey, M, Borghol, A, Moreno, MJ, Nolasco, A,  et al. 2001Cholelithiasic disease and associated factors in a Spanish populationDig Dis Sci46142436PubMedCrossRefGoogle Scholar
  5. 5.
    Jorgensen, T 1989Gall stones in a Danish population. Relation to weight, physical activity, smoking, coffee consumption, and diabetes mellitusGut3052834PubMedCrossRefGoogle Scholar
  6. 6.
    Jorgensen, T, Kay, L, Schultz-Larsen, K 1990The epidemiology of gallstones in a 70-year-old Danish populationScand J Gastroenterol2533540PubMedCrossRefGoogle Scholar
  7. 7.
    McMichael, AJ, Baghurst, PA, Scragg, RK 1992A case-control study of smoking and gallbladder disease: importance of examining time relationsEpidemiology351922PubMedCrossRefGoogle Scholar
  8. 8.
    Misciagna, G, Leoci, C, Guerra, V, Chiloiro, M, Elba, S, Petruzzi, J,  et al. 1996Epidemiology of cholelithiasis in southern Italy. Part II: risk factorsEur J Gastroenterol Hepatol858593PubMedCrossRefGoogle Scholar
  9. 9.
    Martinez de Pancorbo, C, Carballo, F, Horcajo, P, Aldeguer, M, de la Villa, I, Nieto, E,  et al. 1997Prevalence and associated factors for gallstone disease: results of a population survey in SpainJ Clin Epidemiol50134755PubMedCrossRefGoogle Scholar
  10. 10.
    Kratzer, W, Kachele, V, Mason, RA, Muche, R, Hay, B, Wiesneth, M,  et al. 1997Gallstone prevalence in relation to smoking, alcohol, coffee consumption, and nutrition. The Ulm Gallstone StudyScand J Gastroenterol329538PubMedCrossRefGoogle Scholar
  11. 11.
    La Vecchia, C, Decarli, A, Ferraroni, M, Negri, E 1994Alcohol drinking and prevalence of self-reported gallstone disease in the 1983 Italian National Health SurveyEpidemiology55336PubMedGoogle Scholar
  12. 12.
    Kono, S, Eguchi, H, Honjo, S, Todoriki, I, Oda, T, Shinchi, K,  et al. 2002Cigarette smoking, alcohol use, and gallstone risk in Japanese menDigestion6517783PubMedCrossRefGoogle Scholar
  13. 13.
    Spirt, BA, Graves, LW, Weinstock, R, Bartlett, SJ, Wadden, TA 1995Gallstone formation in obese women treated by a low-calorie dietInt J Obes Relat Metab Disord195935PubMedGoogle Scholar
  14. 14.
    Shinchi, K, Kono, S, Honjo, S, Imanishi, K, Hirohata, T 1993Serum lipids and gallstone diseaseAnn Epidemiol36148PubMedCrossRefGoogle Scholar
  15. 15.
    Thijs, C, Knipschild, P, Brombacher, P 1990Serum lipids and gallstones: a case-control studyGastroenterology998439PubMedGoogle Scholar
  16. 16.
    Worthington, HV, Hunt, LP, McCloy, RF, Ubbink, JB, Braganza, JM 2004Dietary antioxidant lack, impaired hepatic glutathione reserve, and cholesterol gallstonesClin Chim Acta34915765PubMedCrossRefGoogle Scholar
  17. 17.
    Welch, GN, Loscalzo, J 1998Homocysteine and atherothrombosisN Engl J Med338104250PubMedCrossRefGoogle Scholar
  18. 18.
    Hankey, GJ, Eikelboom, JW 1999Homocysteine and vascular diseaseLancet35440713PubMedCrossRefGoogle Scholar
  19. 19.
    Shipchandler, MT, Moore, EG 1995Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzerClin Chem419914PubMedGoogle Scholar
  20. 20.
    Broekmans, WM, Klopping-Ketelaars, IA, Shuurman, CR, Verhagen, H, van den Berg, H, Kok, FJ,  et al. 2000Fruits and vegetables increase plasma carotenoids and vitamins and decrease homocysteine in humansJ Nutr130157883PubMedGoogle Scholar
  21. 21.
    Tucker, KL, Selhub, J, Wilson, PW, Rosenberg, IH 1996Dietary intake pattern relates to plasma folate and homocysteine concentrations in the Framingham Heart StudyJ Nutr126302531PubMedGoogle Scholar
  22. 22.
    Nygard, O, Refsum, H, Ueland, PM, Vollset, SE 1998Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine StudyAm J Clin Nutr6726370PubMedGoogle Scholar
  23. 23.
    Andersson, A, Brattstrom, L, Israelsson, B, Isaksson, A, Hamfelt, A, Hultberg, B 1992Plasma homocysteine before and after methionine loading with regard to age, gender, and menoupausal statusEur J Clin Invest227987PubMedCrossRefGoogle Scholar
  24. 24.
    Lussier-Cacan, S, Xhignesse, M, Piolot, A, Selhub, J, Davignon, J, Genest, J,Jr 1996Plasma total homocysteine in healthy subjects: sex-specific relation with biological traitsAm J Clin Nutr6458793PubMedGoogle Scholar
  25. 25.
    Voutilainen, S, Morrow, JD, Roberts, J,II, Alfthan, G, Alho, H, Nyyssonen, K,  et al. 1999Enhanced in vivo lipid peroxidation at elevated plasma total homocysteine levelsArterioscler Thromb Vasc Biol1912636PubMedGoogle Scholar
  26. 26.
    Chambers, JC, McGregor, A, Jean-Marie, J, Obeid, OA, Kooner, JS 1999Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia. An effect reversible with vitamin C therapyCirculation99115660PubMedGoogle Scholar
  27. 27.
    Kanani, PM, Sinkey, CA, Browning, RL, Allaman, M, Knapp, HR, Haynes, WG 1999Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humansCirculation10011618PubMedGoogle Scholar
  28. 28.
    Zhang, F, Slungaard, A, Vercellotti, GM, Iadecola, C 1998Superoxide-dependent cerebrovascular effects of homocysteineAm J Physiol274R170411PubMedGoogle Scholar
  29. 29.
    Loscalzo, J 1996The oxidant stress of hyperhomocyst(e)inemiaJ Clin Invest9857PubMedCrossRefGoogle Scholar
  30. 30.
    Braganza, JM, Worthington, H 1995A radical view of gallstone aetiogenesisMed Hypotheses455106PubMedCrossRefGoogle Scholar
  31. 31.
    Eder, MI, Miquel, JF, Jongst, D, Paumgartner, G, von Ritter, C 1996Reactive oxygen metabolites promote cholesterol crystal formation in model bile: role of lipid peroxidationFree Radic Biol Med207439PubMedCrossRefGoogle Scholar
  32. 32.
    Worthington, HV, Hunt, LP, McCloy, RF, Maclennan, I, Braganza, JM 1997A pilot study of antioxidant intake in patients with cholesterol gallstonesNutrition1311827PubMedCrossRefGoogle Scholar
  33. 33.
    Shiesh, SC, Chen, CY, Lin, XZ, Liu, ZA, Tsao, HC 2000Melatonin prevents pigment gallstone formation induced by bile duct ligation in guinea pigsHepatology3245560PubMedCrossRefGoogle Scholar
  34. 34.
    Ortega, RM, Fernandez-Azuela, M, Encinas-Sotillos, A, Andres, P, Lopez-Sobaler, AM 1997Differences in diet and food habits between patients with gallstones and controlsJ Am Coll Nutr168895PubMedGoogle Scholar
  35. 35.
    Mendez-Sanchez, N, Bahena-Aponte, J, Chavez-Tapia, NC, Motola-Kuba, D, Sanchez-Lara, K, Ponciano-Radriguez, G,  et al. 2005Strong association between gallstones and cardiovascular diseaseAm J Gastroenterol10082730PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 2005

Authors and Affiliations

  • Hidenari Sakuta
    • 1
  • Takashi Suzuki
    • 2
  1. 1.Department of Internal MedicineSelf-Defense Forces Central HospitalTokyoJapan
  2. 2.Department of Research and LaboratorySelf-Defense Forces Central HospitalTokyoJapan

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