Journal of Gastroenterology

, Volume 40, Issue 11, pp 1061–1064 | Cite as

Plasma total homocysteine and gallstone in middle-aged Japanese men

  • Hidenari Sakuta
  • Takashi Suzuki



We wished to determine whether selected coronary risk factors correlated with the presence of gallstone (GS) in middle-aged Japanese men.


We carried out a cross-sectional study of 974 male Self-Defense officials. The odds ratio of a 1-SD increment in levels of coronary risk factors for the presence of GS was calculated in a logistic regression analysis.


Nine subjects had undergone cholecystectomy. Gallstone was detected in 39 subjects and not in 926 subjects. The presence of GS was associated with total homocysteine (tHcy), but not with total cholesterol, triglyceride, γ-glutamyl transferase, glucose, or folate. The odds ratio of a 2.8-µmol/l increase (1 SD) in tHcy levels for the presence of GS was 1.34 (95% confidence interval [CI], 1.05–1.69; P = 0.017), and the ratio was 1.33 (95% CI, 1.04–1.70; P = 0.025) after being adjusted for lifestyle factors, including cigarette smoking, vegetable intake, physical activity, and abstention from alcohol.


Plasma tHcy, but not the other coronary risk factors, correlated with the presence of GS in middle-aged Japanese men. This association may partly explain the reported high prevalence rate of coronary heart disease in subjects with GS.

Key words

gallstone homocysteine oxidative stress smoking vegetable 


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Copyright information

© Springer-Verlag Tokyo 2005

Authors and Affiliations

  • Hidenari Sakuta
    • 1
  • Takashi Suzuki
    • 2
  1. 1.Department of Internal MedicineSelf-Defense Forces Central HospitalTokyoJapan
  2. 2.Department of Research and LaboratorySelf-Defense Forces Central HospitalTokyoJapan

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