Journal of Gastroenterology

, Volume 40, Issue 8, pp 833–835

Safety and efficacy of therapy with botulinum toxin in obesity: a pilot study

  • Giovanni Albani
  • Maria Letizia Petroni
  • Alessandro Mauro
  • Antonio Liuzzi
  • Giovanni Lezzi
  • Barbara Verti
  • Paolo Marzullo
  • Laila Cattani
Rapid communication

Abstract

Background

Botulin toxin (BTX) has been proposed as a potential obesity treatment.

Methods

In a pilot study, the short-term efficacy and safety of BTX was assessed in eight subjects (four men, four women; median age, 46 years; range, 35–57 years) with severe obesity (median body mass index [BMI], 47.1 kg/m2; range 38.2–56.7 kg/m2) and multiple dietary treatment failures. In a single endoscopic session, 500 UI of BTX-A was injected in the gastric antral region.

Results

No clinically significant side effects were observed. In all patients, despite their not being on a specific diet, a reduction of body weight was observed at 1 month (median baseline weight, 124.4 kg vs 121.8 kg at 1 month; P < 0.05). Two treatment-unrelated dropouts were observed. At 4 months, three of the six patients had a further weight loss. The treatment effect was apparently independent of changes in hunger or satiety, or of changes in fasting and postprandial plasma ghrelin and serum leptin, thus suggesting a different pharmacological mechanism.

Conclusions

BTX-A treatment appears to be safe and well tolerated by obese patients, while its short-term efficacy varied widely.

Key words

obesity ghrelin leptin endoscopy botulinum toxin 

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Copyright information

© Springer-Verlag Tokyo 2005

Authors and Affiliations

  • Giovanni Albani
    • 1
  • Maria Letizia Petroni
    • 1
  • Alessandro Mauro
    • 1
  • Antonio Liuzzi
    • 1
  • Giovanni Lezzi
    • 1
  • Barbara Verti
    • 1
  • Paolo Marzullo
    • 1
  • Laila Cattani
    • 1
  1. 1.Divisions of Nutrition and Gastrointestinal RehabilitationIRCCS Istituto Auxologico ItalianoPiancavallo (Verbania)Italy

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