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Journal of Gastroenterology

, Volume 40, Issue 4, pp 414–420 | Cite as

Spontaneous remission of primary diffuse large B-cell gastric lymphoma

  • Jiro Watari
  • Yusuke Saitoh
  • Mikihiro Fujiya
  • Kazumasa Nakamura
  • Yuhei Inaba
  • Kotaro Okamoto
  • Hiroki Tanabe
  • Atsumi Yasuda
  • Naoyuki Miyokawa
  • Yutaka Kohgo
Case report

Abstract

Spontaneous and complete disappearance of diffuse large B-cell lymphoma (DLBL) of the stomach is extremely rare. Although regression of gastric DLBL after eradication of Helicobacter pylori has recently been reported, we present two consecutive cases of stage I DLBL of the stomach which disappeared after only nonspecific therapy, including histamine 2-receptor antagonist (H2RA); both cases were documented histologically and endoscopically. Both patients were positive for H. pylori, and later received H. pylori eradication therapy. The disease has not recurred after 11 and 6 months, respectively. Our cases suggest that the option of combination therapy with H2RA either with or followed by H. pylori eradication is appropriate for consideration as an initial approach in standard therapy for stage I diffuse large B-cell gastric lymphoma.

Key words

gastric malignant lymphoma spontaneous remission histamine 2-receptor antagonist 

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Copyright information

© Springer-Verlag Tokyo 2005

Authors and Affiliations

  • Jiro Watari
    • 1
  • Yusuke Saitoh
    • 1
  • Mikihiro Fujiya
    • 1
  • Kazumasa Nakamura
    • 1
  • Yuhei Inaba
    • 1
  • Kotaro Okamoto
    • 1
  • Hiroki Tanabe
    • 1
  • Atsumi Yasuda
    • 1
  • Naoyuki Miyokawa
    • 2
  • Yutaka Kohgo
    • 1
  1. 1.Third Department of Internal MedicineAsahikawa Medical CollegeAsahikawaJapan
  2. 2.Department of Surgical PathologyAsahikawa Medical CollegeAsahikawaJapan

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