Advertisement

Journal of Gastroenterology

, Volume 40, Issue 2, pp 204–208 | Cite as

Juvenile hepatocellular carcinoma with congestive liver cirrhosis

  • Yuko Izumi
  • Naoki Hiramatsu
  • Ichiyo Itose
  • Takahiro Inoue
  • Akira Sasagawa
  • Satoshi Egawa
  • Tsutomu Nishida
  • Yoshimi Kakiuchi
  • Takashi Toyama
  • Fumihiko Nakanishi
  • Kazuyoshi Ohkawa
  • Kiyoshi Mochizuki
  • Tatsuya Kanto
  • Masahiko Tsujii
  • Tetsuo Takehara
  • Shingo Tsuji
  • Michio Kato
  • Akinori Kasahara
  • Norio Hayashi
Case report

Abstract

A case of juvenile hepatocellular carcinoma (HCC) with congestive liver cirrhosis is reported. The patient was a 21-year-old woman. She had been diagnosed as having transposition of the great arteries, type 2, in 1978. She underwent the Mustard operation, but suffered from chronic heart failure. In 1995, she experienced abdominal pain and underwent examination. The laboratory data were normal, except for elevated total bilirubin (5.2 mg/dl). Blood examinations were performed at frequent intervals, and the total bilirubin level fluctuated between 0.9 and 8.1 mg/dl over the next 4 years, but the transaminase level remained normal. In 1999, she experienced abdominal pain again and was admitted to our hospital. Computed tomography showed four space-occupying lesions in the liver; 45 mm, 20 mm, 12 mm, and 10 mm in size. She was diagnosed as having HCC, and transcatheter arterial chemoembolization and percutaneous ethanol injection therapy were performed. Histology of the cancerous and the noncancerous liver tissue revealed HCC, moderately differentiated type, in cirrhotic liver with congestion. This patient had no background factors of liver disease, except for liver congestion, associated with the chronic heart failure. Because most patients with cardiac cirrhosis die of cardiac disease, only a small number of these patients develop liver failure. However, the incidence of HCC in patients with congestive liver disease is likely to increase in the future, as survival time is prolonged with the advances in treatment for chronic heart failure. Therefore, patients with congestive liver disease should be followed, taking into account the possibility of HCC.

Key words

congestive liver cirrhosis cardiac cirrhosis juvenile hepatocellular carcinoma 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Tokyo 2005

Authors and Affiliations

  • Yuko Izumi
    • 1
  • Naoki Hiramatsu
    • 2
  • Ichiyo Itose
    • 2
  • Takahiro Inoue
    • 3
  • Akira Sasagawa
    • 4
  • Satoshi Egawa
    • 5
  • Tsutomu Nishida
    • 5
  • Yoshimi Kakiuchi
    • 5
  • Takashi Toyama
    • 5
  • Fumihiko Nakanishi
    • 5
  • Kazuyoshi Ohkawa
    • 5
  • Kiyoshi Mochizuki
    • 5
  • Tatsuya Kanto
    • 2
  • Masahiko Tsujii
    • 5
  • Tetsuo Takehara
    • 2
  • Shingo Tsuji
    • 5
  • Michio Kato
    • 1
  • Akinori Kasahara
    • 6
  • Norio Hayashi
    • 2
  1. 1.Department of GastroenterologyOsaka National HospitalOsakaJapan
  2. 2.Department of Molecular TherapeuticsOsaka University Graduate School of MedicineSuitaJapan
  3. 3.Department of Gastroenterology and Metabolic DiseaseOsaka Prefectural HospitalOsakaJapan
  4. 4.Department of GastroenterologyOsaka Minami National HospitalOsakaJapan
  5. 5.Department of Internal Medicine and TherapeuticsOsaka University Graduate School of MedicineOsakaJapan
  6. 6.Department of General MedicineOsaka University Graduate School of MedicineOsakaJapan

Personalised recommendations