Journal of Gastroenterology

, Volume 39, Issue 12, pp 1202–1204 | Cite as

Orally administered Kampo medicine, Juzen-taiho-to, ameliorates anemia during interferon plus ribavirin therapy in patients with chronic hepatitis C

  • Yukihiko Sho
  • Kunio Fujisaki
  • Hironori Sakashita
  • Koichi Yamaguchi
  • Kenji Tahara
  • Osamu Kubozono
  • Akio Ido
  • Hirohito Tsubouchi
Rapid Communication

Abstract

Background

Interferon plus ribavirin (IFN/Rib) therapy is currently standard treatment for chronic hepatitis C. Hemolytic anemia, however, is a serious side effect of this treatment, requiring reductions in or complete withdrawal of ribavirin.

Methods

We retrospectively investigated the effect of the Kampo medicine Juzen-taiho-to (TJ-48), which contains bone marrow-stimulating compounds, on anemia in 67 patients with chronic hepatitis C, who received IFN/Rib therapy.

Results

The reduction in hemoglobin levels was significantly ameliorated in TJ-48-treated patients (P < 0.05). Consequently, only 13% (4/32) of TJ-48-treated patients received altered doses of ribavirin, while the ribavirin dose had to be reduced or withdrawn in 43% (15/35) of patients in the absence of TJ-48 administration (P < 0.001).

Conclusions

These results indicate the possibility that oral administration of TJ-48 supports IFN/Rib therapy without necessitating ribavirin reduction or withdrawal.

Key words

chronic hepatitis C interferon ribavirin Juzen-taiho-to 

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Copyright information

© Springer-Verlag Tokyo 2004

Authors and Affiliations

  • Yukihiko Sho
    • 1
  • Kunio Fujisaki
    • 2
  • Hironori Sakashita
    • 3
  • Koichi Yamaguchi
    • 4
  • Kenji Tahara
    • 5
  • Osamu Kubozono
    • 5
  • Akio Ido
    • 6
    • 7
  • Hirohito Tsubouchi
    • 7
  1. 1.Jiaikai Imamura Bun-in HospitalKagoshimaJapan
  2. 2.Hayato Medical CenterKagoshimaJapan
  3. 3.Jiaikai Imamura HospitalKagoshimaJapan
  4. 4.Yamaguchi Urban ClinicKagoshimaJapan
  5. 5.Kagaoshima Kouseiren HospitalKagoshimaJapan
  6. 6.Department of Experimental Therapeutics, Translational Research CenterKyoto University HospitalKyotoJapan
  7. 7.Department of Internal Medicine II, Faculty of MedicineUniversity of MiyazakiMiyazakiJapan

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