Journal of Gastroenterology

, Volume 39, Issue 2, pp 120–124 | Cite as

Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients

  • Shinichi Fujitake
  • Kenji Hibi
  • Osamu Okochi
  • Yasuhiro Kodera
  • Katsuki Ito
  • Seiji Akiyama
  • Akimasa Nakao
Article

Background

Recently, it was demonstrated that suppressor of cytokine signaling-1 (SOCS-1) was frequently silenced by methylation of its CpG island in human hepatocellular carcinoma (HCC). To define the role of SOCS-1 in the tumorigenic pathway of the colorectum, we examined the methylation of SOCS-1 in tumors of colorectal cancer patients.

Methods

We examined 74 colorectal cancer patients, using a methylation-specific polymerase chain reaction (PCR; MSP) for SOCS-1 CpG island in primary tumors.

Results

Aberrant methylation of the SOCS-1 CpG island was detected in 6 of the 74 (8%) colorectal cancer specimens. No corresponding normal colorectal tissues showed SOCS-1 methylation. We then analyzed the correlation between the clinicopathological features and SOCS-1 aberrant methylation and found that younger age was significantly related to SOCS-1 methylation (P = 0.048).

Conclusions

These findings suggested that SOCS-1 may act as a tumor suppressor in at least some colorectal cancers and that SOCS-1 methylation may be a particular phenomenon related to an early onset of colorectal cancer.

Key words

SOCS-1 methylation colorectal cancer 

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Copyright information

© Springer-Verlag Tokyo 2004

Authors and Affiliations

  • Shinichi Fujitake
    • 1
  • Kenji Hibi
    • 1
  • Osamu Okochi
    • 1
  • Yasuhiro Kodera
    • 1
  • Katsuki Ito
    • 1
  • Seiji Akiyama
    • 1
  • Akimasa Nakao
    • 1
  1. 1.Gastroenterological SurgeryNagoya University Graduate School of MedicineNagoyaJapan

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