Journal of Gastroenterology

, Volume 39, Issue 1, pp 61–63 | Cite as

Inhibitory effect of green tea catechins in combination with sucralfate on Helicobacter pylori infection in Mongolian gerbils

  • Fumiyo Takabayashi
  • Noboru Harada
  • Masami Yamada
  • Binzaburo Murohisa
  • Itaro Oguni
Rapid Communication

Background

The occurrence of antibiotic-resistant Helicobacter pylori has been reported. It is desirable to develop an effective method to prevent the occurrence of resistant strains of Helicobacter pylori. Green tea catechins (GTCs) have been reported to have an antibacterial effect. Therefore, the possibility of eradicating Helicobacter pylori by the oral administration of GTCs was investigated.

Methods

Solutions of GTCs and solutions of GTCs adsorbed to sucralfate (GTC-scf), at concentrations of 20 mg GTCs and/or 20 mg sucralfate/ml were prepared. Then 1 ml of the GTC-scf or the GTC solution was administered daily, for 10 days to Mongolian gerbils infected with Helicobacter pylori. Then the stomachs were extirpated and homogenized. The homogenate was spread on selective medium plates. After 5-day culture, colony-forming units (CFU) of Helicobacter pylori were counted.

Results

The CFU of Helicobacter pylori was significantly decreased by GTC-scf.

Conclusions

GTC-scf may have a bactericidal effect on Helicobacter pylori infection.

Key words

H. pylori stomach ulcer catechin sucralfate 

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Copyright information

© Springer-Verlag Tokyo 2004

Authors and Affiliations

  • Fumiyo Takabayashi
    • 1
  • Noboru Harada
    • 1
  • Masami Yamada
    • 2
  • Binzaburo Murohisa
    • 2
  • Itaro Oguni
    • 3
  1. 1.Shizuoka CollegeUniversity of ShizuokaShizuokaJapan
  2. 2.Hamamatsu Medical CenterHamamatsuJapan
  3. 3.School of Food and Nutritional SciencesUniversity of ShizuokaShizuokaJapan

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