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Journal of Gastroenterology

, Volume 39, Issue 1, pp 50–55 | Cite as

Role of positron emission tomography with 2-deoxy-2-[18F]fluoro-d-glucose in evaluating the effects of arterial infusion chemotherapy and radiotherapy on pancreatic cancer

  • Masato Yoshioka
  • Tsutomu Sato
  • Tomoki Furuya
  • Satoshi Shibata
  • Hideaki Andoh
  • Yoshihiro Asanuma
  • Jun Hatazawa
  • Eku Shimosegawa
  • Kenji Koyama
  • Yuzo Yamamoto
Article

Background

This study evaluated the usefulness of positron emission tomography with 2-deoxy-2-[18F]fluoro-d-glucose (FDG-PET) in monitoring the response to continuous arterial infusion chemotherapy (CAI) combined with external radiation therapy (ERT) for unresectable pancreatic carcinomas.

Methods

Ten patients with unresectable pancreatic cancer were enrolled in this study. Computed tomography (CT) and FDG-PET were done before and after CAI (5-fluorouracil [FU], 500 mg/body per day) combined with ERT (50.4 Gy total dose). Tumor regression was evaluated by standardized uptake value (SUV) with FDG-PET, tumor size on CT, and changes in blood levels of carbohydrate antigen (CA) 19-9. The three methods of evaluation were compared.

Results

The ten patients were classified in three categories. In category I, tumor changes evident on CT and FDG-PET were consistent. In category II, CT could not accurately detect the area of the tumor. However, tumor uptake on FDG-PET decreased markedly after the treatment in category II patients. In category III, both CT and FDG-PET detected the tumor, as in category I. Although there was no definite change in tumor size on CT, FDG-PET uptake was markedly reduced immediately after the treatment. Reduction in tumor size did not appear on CT until 2 months later.

Conclusions

FDG-PET aids in analysis of the effectiveness of chemotherapy and/or radiotherapy.

Key words

FDG-PET pancreatic cancer treatment response arterial infusion chemotherapy radiotherapy 

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Copyright information

© Springer-Verlag Tokyo 2004

Authors and Affiliations

  • Masato Yoshioka
    • 1
  • Tsutomu Sato
    • 1
  • Tomoki Furuya
    • 2
  • Satoshi Shibata
    • 1
  • Hideaki Andoh
    • 1
  • Yoshihiro Asanuma
    • 1
  • Jun Hatazawa
    • 3
  • Eku Shimosegawa
    • 3
  • Kenji Koyama
    • 1
  • Yuzo Yamamoto
    • 1
  1. 1.Department of SurgeryAkita University School of MedicineAkitaJapan
  2. 2.Department of SurgeryAkita City HospitalAkitaJapan
  3. 3.Department of Radiology and Nuclear MedicineAkita Research Institute of Brain and Blood VesselsAkitaJapan

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