Journal of Gastroenterology

, Volume 38, Issue 12, pp 1131–1137 | Cite as

Interaction of Helicobacter pylori-induced follicular gastritis and autoimmune gastritis in BALB/c mice with post-thymectomy autoimmune gastritis

  • Kazuichi Okazaki
  • Masaya Ohana
  • Chikashi Oshima
  • Kazushige Uchida
  • Toshiki Nishi
  • Masahiro Iwano
  • Toshiro Fukui
  • Kimio Kawasaki
  • Minoru Matsuura
  • Masanori Asada
  • Hiroyuki Tamaki
  • Hiroshi Hiai
  • Tsutomu Chiba
Article

Background

There is still controversy about the relationship between Helicobacter pylori infection and autoimmune gastritis. The aim of this study was to clarify whether or not H. pylori infection interacts with the development of autoimmune gastritis.

Methods

Neonatally thymectomized BALB/c mice with autoimmune gastritis received orally administered H. pylori and were examined histologically and serologically. The T-helper (Th)1/Th2 immune balance in the microenvironment of the stomach was evaluated by reverse-transcriptase-polymerase chain reaction (RT-PCR) for interferon (IFN)-Γ and interleukin (IL)-4.

Results

Uninfected mice showed disappearance of parietal cells, and upregulation of IFN-Γ, but no germinal center formation. The infected neonatally thymectomized mice showed follicular gastritis, preserved parietal cells, decreased serum anti-parietal antibodies, and upregulation of IL-4 and IFN-Γ.

Conclusions

H. pylori infection changes the microenvironment of the gastric mucosa by inducing a Th2 immune response in addition to a Th1 response, and regresses autoimmune gastritis in neonatally thymectomized BALB/c mice.

Key words

autoimmune gastritis Helicobacter pylori Th1/2 immune balance 

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Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • Kazuichi Okazaki
    • 1
    • 2
  • Masaya Ohana
    • 1
  • Chikashi Oshima
    • 1
  • Kazushige Uchida
    • 1
  • Toshiki Nishi
    • 1
  • Masahiro Iwano
    • 1
  • Toshiro Fukui
    • 1
  • Kimio Kawasaki
    • 1
  • Minoru Matsuura
    • 1
  • Masanori Asada
    • 1
  • Hiroyuki Tamaki
    • 1
  • Hiroshi Hiai
    • 3
  • Tsutomu Chiba
    • 1
  1. 1.Department of Endoscopic Medicine and GastroenterologyKyoto University HospitalKyotoJapan
  2. 2.Third Department of Internal MedicineKansai Medical UniversityMoriguchiJapan
  3. 3.Department of Pathology and Biology of Diseases, Graduate School of MedicineKyoto UniversityKyotoJapan

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