Journal of Hepato-Biliary-Pancreatic Surgery

, Volume 6, Issue 4, pp 391–395 | Cite as

High serum concentrations of sialyl Tn antigen in carcinomas of the biliary tract and pancreas

  • Atsushi Nanashima
  • Hiroyuki Yamaguchi
  • Tohru Nakagoe
  • Seiji Matsuo
  • Yorihisa Sumida
  • Takashi Tsuji
  • Terumitsu Sawai
  • Eiichirou Yamaguchi
  • Toru Yasutake
  • Hiroyoshi Ayabe
Original article

Abstract:

Sialyl-Tn (STn) antigen is a cancer-associated carbohydrate antigen expressed in cancers of the digestive tract. In the present study, we compared the serum level of STn antigen in 14 patients with benign diseases of the biliary tract and pancreas, 15 patients with bile duct cancers, and 9 patients with cancer of the pancreas. High levels of serum STn (>45 U/ml) were frequently detected in patients with carcinoma of the biliary tract (53.3%) or pancreas (55.6%), compared with the detection of high levels in those with benign diseases (14.3%; P < 0.05). Serum levels of STn did not correlate with the presence of jaundice, cholangitis, or pancreatitis, or with the level of carcinoembryonic antigen (CEA) or carbohydrate antigen (CA) 19-9. In cancer tissues, the expression of STn antigen detected by immunostaining correlated significantly with serum STn (P < 0.05). Our results indicate that measurement of serum STn level may be potentially useful for the diagnosis of carcinomas of the biliary tract and pancreas, particularly when combined with other tumor markers such as CEA or CA19-9.

Key words: biliary tract, pancreas, STn antigen 

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Copyright information

© Springer-Verlag Tokyo 1999

Authors and Affiliations

  • Atsushi Nanashima
    • 1
  • Hiroyuki Yamaguchi
    • 1
  • Tohru Nakagoe
    • 1
  • Seiji Matsuo
    • 1
  • Yorihisa Sumida
    • 1
  • Takashi Tsuji
    • 1
  • Terumitsu Sawai
    • 1
  • Eiichirou Yamaguchi
    • 1
  • Toru Yasutake
    • 1
  • Hiroyoshi Ayabe
    • 1
  1. 1.The First Department of Surgery, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, Nagasaki 852, JapanJP

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