Journal of Hepato-Biliary-Pancreatic Surgery

, Volume 14, Issue 6, pp 586–589

Cystic endocrine tumor of the pancreas with an atypical multilocular appearance

  • Masatoshi Kajiwara
  • Naoto Gotohda
  • Masaru Konishi
  • Toshio Nakagohri
  • Shinichiro Takahashi
  • Motohiro Kojima
  • Takahiro Hasebe
  • Taira Kinoshita
Case reports of interest

Abstract

A 46-year-old woman with epigastric pain was found to have a cystic tumor in the pancreas head on radiological examinations. The tumor was hypervascular, and its multilocular appearance resembled the “honeycomb” pattern of serous cystic tumor (SCT). The patient underwent surgery. The cut surface of the tumor showed a thick fibrous capsule with multiple cystic components, which contained necrotic tissue and brownish serous fluid, indicating an episode of hemorrhage. The cut surface of the tumor resembled solid-pseudopapillary tumor (SPT) on gross appearance. On immunohistochemical staining, the tumor cells showed diffuse and strong staining for synaptophysin (SYN), chromogranin A (CGA), and grimelius, and no staining for α 1-antitrypsin or CD10. We finally made a diagnosis of pancreatic endocrine tumor (PET). As PET sometimes shows an atypical multicystic appearance, immunohistochemical staining is mandatory for its correct diagnosis.

Key words

Cystic endocrine tumor Pancreas Multilocular Immunohistochemical staining 

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Copyright information

© Springer-Verlag Tokyo 2007

Authors and Affiliations

  • Masatoshi Kajiwara
    • 1
  • Naoto Gotohda
    • 1
  • Masaru Konishi
    • 1
  • Toshio Nakagohri
    • 1
  • Shinichiro Takahashi
    • 1
  • Motohiro Kojima
    • 2
  • Takahiro Hasebe
    • 3
  • Taira Kinoshita
    • 1
  1. 1.Department of Hepatobiliary Pancreatic SurgeryNational Cancer Center Hospital EastChibaJapan
  2. 2.Pathology Division, Research Center for Innovative OncologyNational Cancer Center Hospital EastChibaJapan
  3. 3.Surgical Pathology Section, Clinical Laboratory DivisionNational Cancer Center Hospital EastChibaJapan

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