Mucin expression profile in pancreatic cancer and the precursor lesions

  • Kohji Nagata
  • Michiko Horinouchi
  • Miyuki Saitou
  • Michiyo Higashi
  • Mitsuharu Nomoto
  • Masamichi Goto
  • Suguru Yonezawa
Topics: Current understanding of precursors to pancreatic cancer


In this review article, we demonstrate the mucin expression profile in normal tissue, invasive ductal carcinoma (IDC), two subtypes of intraductal papillary–mucinous neoplasm (IPMN dark cell type and IPMN clear cell type), pancreatic intraepithelial neoplasia (PanIN), and mucinous cystic neoplasm (MCN) of the pancreas. In MUC1, there are various glycoforms, such as poorly glycosylated MUC1, sialylated MUC1, and fully glycosylated MUC1. IDCs showed high expression of all the glycoforms of MUC1. IPMNs dark cell type showed no expression or low expression of all the glycoforms of MUC1. IPMNs clear cell type showed low expression of poorly glycosylated MUC1, but expression of sialylated MUC1 and fully glycosylated MUC1. Expression of MUC2 was negative in IDCs, high in IPMNs dark cell type and low in IPMNs clear cell type. MUC5AC was highly expressed in IDCs, IPMNs dark cell type, and IPMNs clear cell type. MUC6 expression was higher in IPMNs clear cell type than in IDCs and IPMNs dark cell type. Our recent study demonstrated that high expression of MUC4 in IDCs is correlated with a poor outcome for patients. In PanINs, expression of both MUC5AC and MUC6 are an early event, whereas up-regulation of MUC1 is a late event. MCNs do not look as if they will show a specific mucin expression profile according to the literature review.

Key words

Pancreas Invasive ductal carcinoma Intraductal–papillary mucinous neoplasm Pancreatic intraepithelial neoplasia Mucinous cystic neoplasm Mucin 


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Copyright information

© Springer-Verlag Tokyo 2007

Authors and Affiliations

  • Kohji Nagata
    • 1
  • Michiko Horinouchi
    • 1
  • Miyuki Saitou
    • 1
  • Michiyo Higashi
    • 1
  • Mitsuharu Nomoto
    • 1
  • Masamichi Goto
    • 1
  • Suguru Yonezawa
    • 1
  1. 1.Department of Human Pathology, Field of OncologyKagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan

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