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Journal of Hepato-Biliary-Pancreatic Surgery

, Volume 13, Issue 2, pp 105–109 | Cite as

Risk factors contributing to hepatic artery thrombosis following living-donor liver transplantation

  • Toshihiko Ikegami
  • Yasuhiko Hashikura
  • Yuichi Nakazawa
  • Koichi Urata
  • Atsuyoshi Mita
  • Yasunari Ohno
  • Masaru Terada
  • Shin-ichi Miyagawa
  • Hideo Kushima
  • Shoji Kondoh
Article

Abstract

Background/Purpose

This study was carried out to investigate the risk factors contributing to hepatic artery thrombosis in living-donor liver transplantation.

Methods

Two hundred and twenty-two recipients (113 adults and 109 children) of living-donor liver transplantation were the subjects of this study. The diagnosis of hepatic artery thrombosis was made by color-Doppler ultrasonography and/or hepatic angiography. Parameters for this study were: (1) donor sex, age, and body weight; (2) recipient sex, age, body weight, liver disease, preoperative prothrombin time, and type of arterial reconstruction; and (3) previous liver transplantation.

Results

Hepatic artery thrombosis occurred in 12 patients (5.4%) at 3 to 15 days posttransplant. Recipient female sex and metabolic disorder as the original disease were found to be significantly associated with hepatic artery thrombosis. The 5-year patient survival rate in recipients with hepatic artery thrombosis (58.3%) was significantly lower than that in recipients without this complication (84.4%).

Conclusions

Female sex and metabolic disease may be factors contributing to hepatic artery thrombosis after living-donor liver transplantation. More intensive anticoagulation therapy for this patient population might decrease the incidence of hepatic artery thrombosis and, thus, posttransplant recipient mortality.

Key words

Sex Metabolic liver disease Vascular reconstruction Anticoagulation 

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Copyright information

© Springer-Verlag Tokyo 2006

Authors and Affiliations

  • Toshihiko Ikegami
    • 1
  • Yasuhiko Hashikura
    • 1
  • Yuichi Nakazawa
    • 1
  • Koichi Urata
    • 1
  • Atsuyoshi Mita
    • 1
  • Yasunari Ohno
    • 1
  • Masaru Terada
    • 1
  • Shin-ichi Miyagawa
    • 1
  • Hideo Kushima
    • 2
  • Shoji Kondoh
    • 2
  1. 1.Department of SurgeryShinshu University School of MedicineMatsumotoJapan
  2. 2.Department of Plastic SurgeryShinshu University School of MedicineMatsumotoJapan

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