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Supportive Care in Cancer

, Volume 7, Issue 6, pp 428–431 | Cite as

Nosocomial candidaemias due to species other than Candida albicans in cancer patients

Aetiology, risk factors, and outcome of 45 episodes within 10 years in a single cancer institution
  • V. Krcmery Jr.
  • M. Mrazova
  • A. Kunova
  • E. Grey
  • J. Mardiak
  • L. Jurga
  • A. Sabo
  • J. Sufliarsky
  • L. Sevcikova
  • D. Sorkovska
  • D. West
  • J. Trupl
  • J. Novotny
  • F. Mateicka
ORIGINAL ARTICLE

Abstract

 Forty-five cases of fungaemia due non-albicans Candida spp. (NAC) in a single National Cancer Institution within 10 years were analysed for aetiology, risk factors and outcome. There had been 12 cases of fungaemia that were due to C. krusei, 14 due to C. parapsilosis, 7 due to C. (T.)glabrata, 6 to C. tropicalis, 2 to C. guillermondii, 2 to C. lusitaniae, 1 to C. stellatoidea, and 1 to C. rugosa. Comparison of 45 NAC fungaemia with 75 episodes of C. albicans fungaemia revealed differences only in two risk factors: previous empiric therapy with amphotericin B (16.0 vs 2.2%, P<0.01) appeared more frequently in cases of C. albicans fungaemia, and prior prophylaxis with fluconazole (8.9 vs 0%, P<0.02) was conversely more frequently observed with NAC. The incidence of other risk factors, such as underlying disease, chemotherapy, antibiotic prophylaxis or therapy, treatment with corticosteroids, catheter insertion, mucositis, cytotoxic chemotherapy, and neutropenia, was similar in both groups. There was no difference either in attributable or in overall mortality between NAC and C. albicans fungaemia in our cancer patients.

Key words Fungaemia Non-albicans Candida spp. Cancer patients 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • V. Krcmery Jr.
    • 1
  • M. Mrazova
    • 2
  • A. Kunova
    • 1
  • E. Grey
    • 2
  • J. Mardiak
    • 1
  • L. Jurga
    • 2
  • A. Sabo
    • 2
  • J. Sufliarsky
    • 1
  • L. Sevcikova
    • 1
  • D. Sorkovska
    • 1
  • D. West
    • 3
  • J. Trupl
    • 1
  • J. Novotny
    • 2
  • F. Mateicka
    • 2
  1. 1.Department of Microbiology, Department of Oncology, National Cancer and St. Elizabeth's Cancer Institutes, Klenova 10, 833 10 Bratislava, Slovak Republic
  2. 2.Department of Medicine, University of Trnava, Hornopotocna 23, 917 43 Trnava, Slovak Republic
  3. 3.University of Scranton, School of Health, Scranton, Pennsylvania, USAUS

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