Supportive Care in Cancer

, Volume 7, Issue 1, pp 28–30 | Cite as

Activity of quinolones against viridans group streptococci isolated from blood cultures of patients with haematological malignancy

  • K. G. Kerr
  • Hannah T. Armitage
  • Paul H. M. McWhinney


Use of fluoroquinolones for antimicrobial prophylaxis during neutropenia is often cited as a significant predisposing factor for viridans group streptococcus (VGS) bacteraemia. Newer compounds in this class are reputed to have enhanced activity against Gram-positive bacteria, and we determined the minimal inhibitory concentrations (MICs) for ciprofloxacin and three of the newer compounds: trovafloxacin, fleroxacin and clinafloxacin, against 44 isolates of VGS. On a gravimetric basis, clinafloxacin was most active (MIC90 0.19 mg/l), whereas ciprofloxacin and fleroxacin were the least active (both MIC90 16 mg/l). Clinafloxacin warrants further study as an agent of prophylaxis against bacterial infection in neutropenic patients.

Key words Viridans group streptococci Quinolone Neutropenia Chemoprophylaxis 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • K. G. Kerr
    • 1
  • Hannah T. Armitage
    • 2
  • Paul H. M. McWhinney
    • 3
  1. 1.Department of Microbiology, University of Leeds, Leeds LS2 9JT, UK Tel.: +44 113 233 5617 Fax: +44 113 233 5649 email: GB
  2. 2.Department of Microbiology, Leeds General Infirmary, Leeds LS1 3EX, UKGB
  3. 3.Department of Infectious Diseases, Seacroft Hospital, Leeds, UKGB

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