Impact of the antifermentative diet during radiotherapy for prostate cancer in elderly, SÃO Paulo, Brazil
Assess the impact of the antifermentative diet on the dietary intake and body composition of elderly prostate cancer patients in radiotherapy.
Observational and prospective study involving 45 men aged 60 years or older, receiving radiotherapy for prostate cancer treatment. The dietary intake was assessed at four times during radiotherapy: onset (TPre), between the 11th and 16th day (T1), between the 24th and 28th day (T2), and on the last day (TLast). The body composition was assessed before and on the last day of radiotherapy, by means of the body weight and height, mid-arm circumference, triceps and subscapular skin folds, phase angle, resistance, and reactance. The data were statistically treated, considering a 5% significance level.
The intake of energy, dietary fibers, and some nutrients decreased during the radiotherapy (p < 0.05). The intake of vitamins E, B1, B2, and folate, of the minerals calcium, magnesium, potassium, sodium, and phosphorus, and of the amino acid leucine dropped when the four assessment times were compared (p < 0.05). As regards the body composition, an impact was observed at the end of the radiotherapy, with lower body weight, arm circumference, subscapular cutaneous fold, phase angle and reactance (p < 0.05).
The antifermentative diet negatively influenced the food consumption and body composition of elderly patients submitted to radiotherapy for prostate cancer.
KeywordsProstate cancer Radiotherapy Dietary intake Body composition Aged
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
We hold total control over all primary data and agree to allow the journal to review the data upon request.
All procedures performed with the participants were in accordance with the ethical standards of the institutional research committee of the São Judas Tadeu University (USJT) and the Hospital Beneficência Portuguesa de São Paulo (BPSP), under number 119636/2016.
- 1.World Health Organization (2016) Multisectoral action for a life course approach to healthy ageing: draft global strategy and plan of action on ageing and health. https://apps.who.int/iris/bitstream/handle/10665/252671/A69_17-en.pdf?sequence=1&isAllowed=y.
- 2.International Agency for Research on Cancer (2018) Estimated age-standardized mortality rates (World) in 2018, all cancers, males, all ages. http://gco.iarc.fr/today/online-analysis-map.
- 4.Smitsmans MHP, Pos FJ, Bois J, Heemsbergen WD, Sonke IJ, Leberque IV, Herk MV (2008) The influence of a dietary protocol on cone beam CT-guided radiotherapy for prostate cancer patients. I J Radiation Oncology Biol Phys 71(4):1279–1286. https://doi.org/10.1016/j.ijrobp.2008.03.036 CrossRefGoogle Scholar
- 5.American Cancer Society (2014) Low fiber foods. http://www.cancer.org/Treatment/SurvivorshipDuringandAfterTreatment/NutritionforPeoplewithCancer/low-fiber-foods.
- 6.Mayo Clinic (2014) Low-fiber diet. http://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/low-fiber-diet/art-20048511?pg=2.
- 8.Henson CC, Burden S, Davidson SE (2013) Nutritional intervention for reducing gastrointestinal toxicity in adults undergoing radical pelvic radiotherapy. Cochrane Database of Systematic Review 26(11):1–47. https://doi.org/10.1002/14651858.CD009896.pub2/abstract
- 12.Pair ML, Weiliang D, Rojas HD, Kanke JE, Mc Guirre SE, Lee AK, Kuban DA, Kudchacker RJ (2013) Dosimetric effects of weight loss or gain during volumetric modulated arc therapy and intensity-modulated radiation therapy for prostate cancer. Med Dosim 38:251–254. https://doi.org/10.1016/j.meddos.2013.02.004 CrossRefPubMedGoogle Scholar
- 15.Wedlake L, Shaw C, McNair H et al (2017) Randomized controlled trial of dietary fiber for the prevention of radiation-induced gastrointestinal toxicity during pelvic radiotherapy. Am J Clin Nutr. https://doi.org/10.3945/ajcn.116.150565
- 16.Higuera-Pulgar I, Ribed A, Carrascal-Fabian ML, Bretón-Lesmes I, Romero-Jiménez RM, Cuerda-Compes C, Velasco-Gimeno C, Camblor-Álvarez M, García-Peris P (2015) Ingesta dietética y estado nutricional de pacientes oncológicos que inician tratamiento com inhibidores tirosina quisana. Nutr Hosp 32(3):1200–1207 https://doi.org/10.3305/nh.2015.32.3.9315 CrossRefPubMedGoogle Scholar
- 18.Malihi Z, Kandiah M, Chan YM, Esfandbod M, VakilI M, Hosseinzadeh M, Zarif YM (2015) The effect of dietary intake changes on nutritional status in acute leukaemia patients after first induction chemotherapy. European Journal of Cancer Care 24:542–552. https://doi.org/10.1111/ecc.12262 CrossRefPubMedGoogle Scholar
- 19.Silva HGV, Andrade CF, Moreira ASB (2014) Dietary intake and nutritional status in cancer patients: comparing adults and older adults. Nutr Hosp 29:907–912Google Scholar
- 21.Deutz NE, Bauer JM, Barazzoni R, Biolo G, Boirie Y, Bosy-Westphal A, Cederholm T, Cruz-Jentoft A, Krznariç Z, Nair KS, Singer P, Teta D, Tipton K, Calder PC (2014) Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN Expert Group. Clin Nutr 33(6):929–936 https://doi.org/10.1016/j.clnu.2014.04.00 CrossRefPubMedPubMedCentralGoogle Scholar
- 23.Brasil. Resolução RDC no. 344 (2002) Regulamento técnico para a Fortificação das Farinhas de Trigo e das Farinhas de Milho com Ferro e Ácido Fólico. http://portalanvisagovbr/documents/10181/2718376/RDC_344_2002_COMPpdf Accessed 05 January 2018
- 26.Hilal Z, Rezniczek GA, Klenke R, Dogan A, Tempfer CB (2017) Nutritional status, cachexia, and anorexia in women with peritoneal metastasis and intraperitoneal chemotherapy: a longitudinal analysis. J Gynecol Oncol 28(6). https://doi.org/10.3802/jgo.2017.28.e80
- 29.Motta RST, Castanho IA, Velarde LGC (2015) Cutoff point of the phase angle in pre-radiotherapy cancer patients. Nutr Hosp 32(5):2253–2260. https://doi.org/10.3305/nh.2015.32.5.9626
- 30.Bourdel-Marchasson I, Diallo A, Bellera C, Blanc-Bisson C, Durrieu J, Germain C, Mathoulin-Pélissier S, Soubeyran P, Rainfray M, Fonck M, Doussau A (2016) One-year mortality in older patients with cancer: development and external validation of an MNA-based prognostic score. PLoS One 11(2). https://doi.org/10.1371/journal.pone.0148523 CrossRefGoogle Scholar
- 33.Whelan K, Martin LD, Staudacher HM, Lomer MCE (2018) The low FODMAP diet in the management of irritable bowel syndrome: an evidence-based review of FODMAP restriction, reintroduction and personalization in clinical practice. J Hum Nutr Diet 31:239–255. https://doi.org/10.1111/jhn.12530 CrossRefPubMedGoogle Scholar