Supportive Care in Cancer

, Volume 28, Issue 2, pp 419–420 | Cite as

Letter to the Editor: Re: “Is heart rate variability a valuable method to investigate cardiac autonomic dysfunction in subjects with leukemia? A systematic review to evaluate its importance in clinical practice” by Kirizawa et al

  • Maxime CaruEmail author
  • Daniel Curnier
Letter to the Editor

Researcher Kirizawa and colleagues recently published a systematic review in the Supportive Care in Cancer on the importance of using heart rate variability (HRV) to investigate cardiac autonomic dysfunction in patients with leukemia [1]. In the light of this study, it seems obvious that HRV will be used in cancer clinical practice, especially because HRV provided valuable information for patients under physiological and pathological conditions. Unfortunately, cardiac autonomic dysfunction is a widely underestimated risk in leukemia patients. With this letter to the editor, we would like to comment on the importance of systematic reviews as a form of evidence in research. We agree with the authors that some questions deserve to be answered regarding leukemia populations to better understand the late adverse effects of cancer and treatments on patients’ cardiac autonomic dysfunction. Moreover, we agree with researchers’ point of view on the importance of HRV in the diagnosis of...


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Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Laboratory of Pathophysiology of EXercise (LPEX), School of Kinesiology and Physical Activity Sciences, Faculty of MedicineUniversity of MontrealMontrealCanada
  2. 2.Sainte-Justine University Health Center, Research CenterMontrealCanada
  3. 3.Laboratoire EA 4430—Clinique Psychanalyse Developpement (CliPsyD), Department of psychologyUniversity of Paris NanterreNanterreFrance

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