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Supportive Care in Cancer

, Volume 28, Issue 1, pp 361–372 | Cite as

The risk of bloodstream infection associated with totally implantable venous access ports in cancer patient: a systematic review and meta-analysis

  • Meng JiangEmail author
  • Chang-li Li
  • Chun-qiu Pan
  • Li Yu
Original Article
  • 245 Downloads

Abstract

Objective

This systematic review and meta-analysis aimed to provide evidence-based guidance to better understand the risk of central line-associated bloodstream infection (CLABSI) in cancer patients who received totally implantable venous access ports (TIVAPs) compared with those who received external central venous catheters (CVCs).

Methods

A systematic search of PubMed, Web of science, Embase, and the Cochrane Library was carried out from inception through Oct 2018, with no language restrictions. Trials examining the risk of CLABSI in cancer patients who received TIVAPs compared with those who received external CVCs were included. Two reviewers independently reviewed, extracted data, and assessed the risk of bias of each study. A random-effect model was used to estimate relative risks (RRs) with 95% CIs.

Results

In all, 26 studies involving 27 cohorts and 5575 patients reporting the incidence of CLABSI in patients with TIVAPs compared with external CVCs were included. Pooled meta-analysis of these trials revealed that TIVAPs were associated with a significant lower risk of CLABSI than were external CVCs (relative risk [RR], 0.44; 95% confidence interval [CI], 0.31–0.62; P < 0.00001), which was confirmed by trial sequential analysis for the cumulative z curve entered the futility area. Subgroup analyses demonstrated that CLABSI reduction was greatest in adult patients (RR [95% CI], 0.35 [0.22–0.56]) compared with pediatric patients who received TIVAPs (RR [95% CI], 0.55 [0.38–0.79]).

Conclusions

TIVAP can significantly reduce the risk of CLABSI compared with external CVCs.

Keywords

Totally implantable venous access ports External central venous catheters Central line-associated bloodstream infection Meta-analysis 

Notes

Funding

This work was supported by grants from the President Foundation of Nanfang Hospital of Southern Medical University (Grant No.2016B012) and grants from President Foundation of Nanfang Hospital, Southern Medical University (CX2018NO13).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interests. We have full control of all primary data and agree to allow the journal to review our data if requested.

Supplementary material

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Fig. S1

Test for publication bias. (PNG 77 kb)

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High resolution image (TIF 11987 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Emergency Medicine, Nanfang HospitalSouthern Medical UniversityGuangzhouChina
  2. 2.Department of GeratologyHubei Provincial Hospital of Integrated Chinese and Western medicineWuhanChina
  3. 3.Department of Critical Care Medicine, Wuhan Central Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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