Mood outcomes of a behavioral treatment for urinary incontinence in prostate cancer survivors
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This study aimed to assess whether prostate cancer survivors who received a behavioral intervention to urinary incontinence had experienced a significant mood improvement.
One hundred fifty-three prostate cancer survivors with persistent incontinence were included in this secondary data analysis. They were randomly assigned to usual care or interventions that provided pelvic floor muscle exercises and self-management skills. All subjects had measures of anxiety, depression, and anger at baseline, 3 months (post-intervention), and 6 months (follow-up). Negative binomial regression analysis was performed to examine the group status, daily leakage frequency at 3 months, and their interactions at 3 months as predictors for mood outcomes at 6 months, controlling for demographic and medical variables.
The main effect of daily leakage frequency at 3 months significantly predicted anxiety at 6 months (p < .01). The group main effect on any mood outcomes at 6 months was not statistically significant. The interaction between the group and 3-month leakage had a significant effect on anxiety; intervention subjects achieving a significant leakage reduction at 3 months exhibited significantly less anxiety at 6 months than other subjects (p = .04). Age, employment status, and receiving surgery at baseline were significantly associated with less anxiety, depression, and anger at 6 months.
Reduced urinary incontinence significantly predicted less anxiety, especially among the intervention subjects. The findings suggest a significant association between a behavioral therapy of urinary incontinence and anxiety reduction in prostate cancer survivors.
KeywordsBehavioral intervention Anxiety Cancer care Prostate cancer Psychosocial studies
All the authors have contributed to this article through research participation, data collection or data analysis, and manuscript production.
The study was supported by the National Institutes of Health/National Cancer Institute (R01CA127493; PI: Zhang). Cleveland Clinic, University Hospitals Cleveland Medical Center, Louis Stokes Cleveland Veterans Affairs Medical Center, and the MetroHealth System, which are all affiliated with Case Western Reserve University, provided support for patient access.
Compliance with ethical standards
Conflict of interest
The authors declare that they do not have a financial relation with the funding agency NIH except for honoraria received when performing grant reviews. The authors have full control of the primary data that is available for the journal’s review if requested.
Informed consent was obtained from all individual participants included in the study. This study has not been published and is not under consideration for publication elsewhere. All authors have contributed to this article through research participation, data collection or data analysis, and manuscript production. They provided financial disclosure under the Conflict of Interest.
- 1.Kollberg KS, Wilderäng U, Thorsteinsdottir T, Hugosson J, Wiklund P, Bjartell A, Carlsson S, Stranne J, Haglind E, Steineck G (2017) How badly did it hit? Self-assessed emotional shock upon prostate cancer diagnosis and psychological well-being: a follow-up at 3, 12, and 24 months after surgery. Acta Oncol 56:984–990CrossRefGoogle Scholar
- 2.Lane A, Metcalfe C, Young GJ, Peters TJ, Blazeby J, Avery KN, Dedman D, Down L, Mason MD, Neal DE, Hamdy FC, Donovan JL, ProtecT Study group (2016) Patient-reported outcomes in the ProtecT randomized trial of clinically localized prostate cancer treatments: study design, and baseline urinary, bowel and sexual function and quality of life. BJU Int 118(6):869–879CrossRefGoogle Scholar
- 5.Watson E, Shinkins B, Frith E, Neal D, Hamdy F, Walter F, Weller D, Wilkinson C, Faithfull S, Wolstenholme J, Sooriakumaran P, Kastner C, Campbell C, Neal R, Butcher H, Matthews M, Perera R, Rose P (2016) Symptoms, unmet needs, psychological well-being and health status in survivors of prostate cancer: implications for redesigning follow-up. BJU Int 117:E10–E19CrossRefGoogle Scholar
- 7.ACS (2017) Cancer Facts & Figures. American Cancer Society, Inc., AtlantaGoogle Scholar
- 19.KÖhler N, Friedrich M, Gansera L, Holze S, Thiel R, Roth S, Rebmann U, Stolzenburg JU, Truss MC, Fahlenkamp D, Scholz HJ, Brahler E (2014) Psychological distress and adjustment to disease in patients before and after radical prostatectomy. Results of a prospective multi-centre study. Eur J Cancer Care 23:795–802CrossRefGoogle Scholar
- 21.Sciarra A, Gentilucci A, Salciccia S, Von Heland M, Ricciuti GP, Marzio V, Pierella F, Musio D, Tombolini V, Frantellizzi V, Pasquini M, Maraone A, Guandalini A, Maggi M (2018) Psychological and functional effect of different primary treatments for prostate cancer: a comparative prospective analysis. Urol Oncol 36(7):340.e7–340.e21CrossRefGoogle Scholar
- 22.Sharpley CF, Bitsika V, Christie DRH, Bradford R, Steigler A, Denham JW (2017) Psychological resilience aspects that mediate the depressive effects of urinary incontinence in prostate cancer survivors 10 years after treatment with radiation and hormone ablation. J Psychosoc Oncol 35(4):438–450CrossRefGoogle Scholar
- 25.Dess RT, Jackson WC, Suy S, Soni PD, Lee JY, Abugharib AE, Zumsteg ZS, Feng FY, Hamstra DA, Collins SP, Spratt DE (2017) Predictors of multidomain decline in health-related quality of life after stereotactic body radiation therapy (SBRT) for prostate cancer. Cancer 123(9):1635–1642CrossRefGoogle Scholar
- 28.Anderson CA, Omar MI, Campbell SE, Hunter KF, Cody JD, Glazener CMA (2015) Conservative management for postprostatectomy urinary incontinence. Cochrane Database Syst Rev 2015(1):CD001843. https://doi.org/10.1002/14651858.CD001843.pub5
- 36.McNair DM, Lorr M, Droppleman LF (1992) EdITS Manual for the Profile of Mood States (POMS) (revised ed.). Educational and Testing Service, San DiegoGoogle Scholar