High adherence of patients with multiple myeloma who receive treatment with immunomodulatory drugs (IMIDS) in hematology/oncology group practices in Germany

  • Stefan FeitenEmail author
  • Geothy Chakupurakal
  • Hans Peter Feustel
  • Michael Maasberg
  • Burkhard Otremba
  • Peter Ehscheidt
  • Manfred Hensel
  • Richard Hansen
  • Rudolf Weide
Original Article



Immunomodulatory drugs (IMIDS) have changed the treatment and outcome of patients suffering from multiple myeloma. However, with the oral administration adherence becomes an issue. Since there is no “gold standard” in measuring adherence, we assessed the adherence of myeloma patients with the help of different data sources.


All patients who have been receiving IMIDS for at least 3 months were eligible. Computer assisted personal interviews of patients and, if possible, their caregivers were carried out. Attending oncologists evaluated the patient’s adherence with the help of a standardized questionnaire. In addition, a retrospective analysis of prescription data was conducted. All data were analyzed statistically using SPSS.


One hundred myeloma patients, 35% female, 65% male, with a median age of 70 years (37–86) were interviewed. Prescription data could be evaluated in terms of adherence in 78 patients (78%), 56 caregivers could be questioned (56%). Ninety-seven percent of patients rated themselves as adherent in taking IMIDS. Data from treating oncologists, caregivers and prescriptions supported this result. IMID therapies were rated as very effective and significant, toxicities were acceptable and dosing regimens simple/uncomplicated.


Myeloma patients seem to be highly adherent to IMID treatments.


Multiple myeloma Adherence Compliance Immunomodulatory drugs IMIDS Outpatient treatment 



Thanks to Vera Friesenhahn and Kristina Kleboth for their support in running this study and to all study nurses who carried out the interviews.


This work was supported through a restricted grant from Celgene GmbH, Germany. Celgene had no role in gathering, analyzing, or interpreting the data.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Stefan Feiten
    • 1
    Email author
  • Geothy Chakupurakal
    • 2
  • Hans Peter Feustel
    • 3
  • Michael Maasberg
    • 4
  • Burkhard Otremba
    • 5
  • Peter Ehscheidt
    • 6
  • Manfred Hensel
    • 7
  • Richard Hansen
    • 8
  • Rudolf Weide
    • 2
  1. 1.Institut für Versorgungsforschung in der OnkologieKoblenzGermany
  2. 2.Praxisklinik für Hämatologie und OnkologieKoblenzGermany
  3. 3.Onkologische SchwerpunktpraxisSpeyerGermany
  4. 4.Onkologische GemeinschaftspraxisMayenGermany
  5. 5.Onkologische PraxisOldenburg/DelmenhorstGermany
  6. 6.Onkologische Praxis Dr. EhscheidtNeuwiedGermany
  7. 7.Mannheimer Onkologie PraxisMannheimGermany
  8. 8.Onkologische SchwerpunktpraxisKaiserslauternGermany

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