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Effectiveness and safety of the pre-prescription of garenoxacin in comparison to moxifloxacin for low-risk febrile neutropenia in breast cancer patients undergoing adjuvant and neoadjuvant chemotherapy

  • Masaya Takahashi
  • Katsuyuki Takahashi
  • Kazuki Ogawa
  • Tsutomu Takashima
  • Yuka Asano
  • Shinichiro Kashiwagi
  • Satoru Noda
  • Naoyoshi Onoda
  • Masaichi Ohira
  • Katsuya Nagayama
Original Article
  • 39 Downloads

Abstract

Purpose

The purpose of this study was to compare the efficacy of the pre-prescription of garenoxacin mesylate hydrate (GRNX) with that of moxifloxacin hydrochloride (MFLX) in the management of breast cancer patients with low-risk febrile neutropenia.

Methods

Data from female patients who had been instructed to take previously prescribed oral GRNX or MFLX for 3 days during adjuvant and neoadjuvant chemotherapy if their body temperature exceeded 38 °C were analyzed. This study compared the effectiveness between these fluoroquinolones using a propensity score matching analysis.

Results

The 330 patients received 1192 administrations of chemotherapy between May 2007 and April 2014 and 136 (41.2%) patients had a total of 212 (17.8%) febrile episodes. The frequencies of febrile episodes were 19.5% (113/579) and 16.2% (99/613) in the GRNX and MFLX groups, respectively. After propensity score matching, 384 episodes were matched in each group. Febrile events occurred in 80 and 56 cases in the GRNX and MFLX groups, respectively. Treatment success was identified in 80.0% (64/80) of cases in the GRNX group and 64.3% (36/56) of cases in the MFLX group (P = 0.0494). Additionally, the therapeutic use of granulocyte-colony stimulating factor was 6.3% (5/80) of cases in the GRNX group and 17.9% (10/56) of cases in the MFLX group (P = 0.0498). There were few differences in the frequency of adverse effects between the two groups.

Conclusions

These results indicate that the pre-prescription of GRNX may be a more effective option for the management of low-risk febrile neutropenia during adjuvant and neoadjuvant chemotherapy for breast cancer.

Keywords

Pre-prescription Garenoxacin Moxifloxacin Low-risk febrile neutropenia Breast cancer Adjuvant chemotherapy 

Abbreviations in Figures and Tables

GRNX

garenoxacin mesylate hydrate

MFLX

moxifloxacin hydrochloride

BSA

body surface area

BMI

body mass index

FEC100

5-fluorouracil, epirubicin, cyclophosphamide

AC

adriamycin, cyclophosphamide

TC

docetaxel, cyclophosphamide

AST

aspartate aminotransferase

ALT

alanine aminotransferase

G-CSF

granulocyte-colony stimulating factor

FN

febrile neutropenia

Notes

Acknowledgments

We would like to thank Editage (www.editage.jp) for English language editing.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Research involving human participants and/or animals

This study was approved by the Human Subjects Review Committee at Osaka City University (No. 3725).

Informed consent

For this type of study, formal consent is not required.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Masaya Takahashi
    • 1
  • Katsuyuki Takahashi
    • 1
  • Kazuki Ogawa
    • 1
  • Tsutomu Takashima
    • 2
  • Yuka Asano
    • 2
  • Shinichiro Kashiwagi
    • 2
  • Satoru Noda
    • 2
  • Naoyoshi Onoda
    • 2
  • Masaichi Ohira
    • 2
  • Katsuya Nagayama
    • 1
  1. 1.Department of PharmacyOsaka City University HospitalOsakaJapan
  2. 2.Department of Breast and Endocrine SurgeryOsaka City University Graduate School of MedicineOsakaJapan

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