Supportive Care in Cancer

, Volume 27, Issue 7, pp 2507–2515 | Cite as

Incidence and predictors of venous thromboembolism in medically ill hospitalized elderly cancer patients: a prospective observational study

  • Jeong-Ok Lee
  • Ji Yun Lee
  • Eun Ju Chun
  • Sang Il Choi
  • Jin Won Kim
  • Se Hyun Kim
  • Yu Jung Kim
  • Keun-Wook Lee
  • Jee Hyun Kim
  • Jong Seok Lee
  • Soo-Mee BangEmail author
Original Article



The aim of this study was to estimate the incidence and predictors of venous thromboembolism (VTE) in medically ill hospitalized elderly cancer patients in a single Korean tertiary hospital.


Patients were examined for deep vein thrombosis (DVT) by duplex and color Doppler ultrasonography (DUS) of both legs between days 5 and 14 of their hospital stays. The primary endpoint was the incidence of VTE by day 14, which was determined via a composite of DVT detected by routine DUS and symptomatic VTE.


A total of 140 patients with 31 hematologic and 109 nonhematologic malignancies were analyzed. The median age was 73 years, and 45.7% of the patients were female. The median length of hospital stay was 12 days. The modified Padua prediction score (PPS) ≥ 4 was 92.9%. The incidence of VTE by day 14 was 7.1%, including six proximal and four distal DVT cases. Being female, having a length of hospital stay of ≥ 13 days, and having a modified Padua prediction score of ≥ 6 were risk factors of VTE in univariate analysis. The incidence of VTE was 2.3%, 7.3%, and 41.7% in patients with 0–1, 2, and 3 of these risk factors, respectively.


The incidence of VTE in medically ill hospitalized elderly cancer patients was lower in Korean patients than in Western patients. However, the risk of VTE in those with more than two risk factors (female, long length of hospitalization, and high PPS) increased considerably, and pharmacologic thromboprophylaxis is warranted in these cases.


Cancer Venous thromboembolism Elderly Hospitalized Risk factors 


Financial support

This study was supported by a grant from Seoul National University Bundang Hospital Research Fund (grant no.04-2012-003).

Compliance with ethical standards

This study was approved by the Institutional Review Board at SNUBH (IRB number: B-1201-144-007). Written informed consent was obtained from the patients prior to study entry, and this study was conducted in accordance with the principles of the Declaration of Helsinki.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Jeong-Ok Lee
    • 1
  • Ji Yun Lee
    • 1
  • Eun Ju Chun
    • 2
  • Sang Il Choi
    • 2
  • Jin Won Kim
    • 1
  • Se Hyun Kim
    • 1
  • Yu Jung Kim
    • 1
  • Keun-Wook Lee
    • 1
  • Jee Hyun Kim
    • 1
  • Jong Seok Lee
    • 1
  • Soo-Mee Bang
    • 1
    Email author
  1. 1.Department of Internal Medicine, Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam-siRepublic of Korea
  2. 2.Department of Radiology, Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnamRepublic of Korea

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