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Physical activity and associations with treatment-induced adverse effects among prostate cancer patients

  • Synne-Kristin Hoffart Bøhn
  • Sophie Dorothea Fosså
  • Torbjørn Wisløff
  • Lene Thorsen
Original Article

Abstract

Purpose

The present study aimed to determine the level of physical activity (PA) among prostate cancer (PCa) patients across treatment modalities and explore the association between PA and treatment-induced adverse effects (AEs).

Methods

The present study was based on a cross-sectional postal survey among members of the Norwegian Prostate Cancer Association. Patients were eligible for the present study if they had either (1) completed radical prostatectomy, (2) completed radiotherapy and (neo)-adjuvant androgen deprivation therapy (ADT), or (3) were undergoing lifelong ADT. Adverse effects were measured by the Expanded Prostate Cancer Index Composite for Clinical Practice.

Results

In total, 696 patients were included. There was no statistically significant difference in level of PA across treatment modalities. Bowel symptoms mainly related to radiotherapy decreased the odds of exercising ≥ 2 times per week, along with age ≥ 70 years, participation in the workforce, and BMI ≥ 25 kg/m2. Among patients who were undergoing ADT, 5 years or more since diagnosis reduced the odds of exercising ≥ 2 times per week by almost 60%.

Conclusion

The level of PA did not differ across PCa patients treated with different modalities. Increasing bowel symptoms reduced the likelihood of exercising ≥ 2 times per week. PCa patients should be educated about possible treatment-induced AEs affecting PA level, enabling them to counteract the development of physical inactivity.

Keywords

Prostate cancer Physical activity Treatment-induced adverse effects Radiotherapy Androgen deprivation therapy Prostatectomy 

Notes

Funding

This study was funded by the Norwegian Cancer Society (project no. 45980 – Norwegian Consortium on Late Effects after Cancer).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.National Advisory Unit on Late Effects after Cancer Treatment, Department of OncologyOslo University Hospital OsloNorway
  2. 2.Faculty of MedicineUniversity of OsloOsloNorway
  3. 3.Department of Infectious Disease Epidemiology and Modelling, Norwegian Institute of Public Health, and Department of Health Management and Health EconomicsUniversity of OsloOsloNorway
  4. 4.Department of Clinical ServiceOslo University HospitalOsloNorway

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