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Supportive Care in Cancer

, Volume 26, Issue 9, pp 3021–3027 | Cite as

Multidrug-resistant bacterial microorganisms (MDRO) in end-of-life care: development of recommendations for hospitalized patients using a mixed-methods approach

  • Maria Heckel
  • Stephanie Stiel
  • Franziska A. Herbst
  • Johanna M. Tiedtke
  • Alexander Sturm
  • Thomas Adelhardt
  • Christian Bogdan
  • Cornel Sieber
  • Oliver Schöffski
  • Frieder R. Lang
  • Christoph Ostgathe
Original Article

Abstract

Purpose

Palliative care professionals are frequently confronted with patients colonized or infected with MDRO. One major challenge is how to balance necessary isolation measures and social inclusion as one of the main principles of palliative and end-of-life care. To date, MDRO-specific policies and protocols vary widely between institutions. Aim: provide empirical recommendations on how to deal with hospitalized MDRO patients in end-of-life care.

Methods

Recommendations were developed based on (i) initial results of face-to-face interviews and focus groups, (ii) impartial experts’ comments and consensus on the draft via online survey and (iii) a face-to-face meeting with consortium members to finalize recommendations. Findings of 158 interviews and six focus groups (39 participants) with patients, family caregivers, staff members and institutional stakeholders contributed to the recommendations. The assessments of 17 experts were considered.

Results

In total, 21 recommendations were approved. The recommended strategy in dealing with MDRO at the end of life allows case-based application of protection and isolation measures. MDRO diagnostics and therapy involve screening at admission. The recommendations suggest consideration of required accommodation facilities, provided material as well as staff and time resources. The recommendations further highlight the importance of providing for strategies enabling the patient’s social inclusion and provision of verbal and written information about MDRO for patients and family caregivers, transparent medical documentation, and staff member training.

Conclusion

The recommendations summarize the perspectives of individuals and groups affected by MDRO at the end of life and provide practical guidance for clinical routine. Further dissemination and implementation requirements are discussed and should contain the evaluation of the knowledge, views, worries, and anxieties of the target groups.

Keywords

Palliative care Terminal care Drug resistance Multiple Practice guideline Methicillin-resistant Staphylococcus aureus Empirical research 

Notes

Author contributions

TA, MH, FAH, TA, JMT and AS designed the interview guides and conducted the interviews. TA, FAH, TA, JMT and AS conducted the focus groups. MH, FAH, TA, JMT, AS and SS analyzed the data. SS, CO, FRL, OS, CB and CS designed the research project, obtained funding and provided guidance regarding the general direction of the project. They were contributors to research conception and design. MH, FAH and SS drafted the recommendations. CB, CO, OS, CS, SS TA, FAH, AS and JMT took part in the consortium member consensus meeting. MH was the primary author. FAH, SS and CO were key contributors in writing the manuscript. TA, JMT, AS, SS, FRL, OS, CB and CS revised the draft manuscript. All authors read and approved the final manuscript for submission.

The present work was performed in partial fulfillment of the requirements for obtaining the degree “Dr. rer. biol. hum.” for the primary author MH.

Funding

This study is part of the project “M-EndoL—MRSA in end-of-life care” which was conducted with generous financial support from the German Federal Ministry of Education and Research (BMBF) (grant nr 01GY1314) and administratively monitored by the DLR Project Management Agency. The funding source was not involved in study design; in the collection, analysis and interpretation of data; in the writing of the report and in the decision to submit the paper for publication. Layout and print of the recommendations’ publication were funded by the German Association of Palliative Care (Deutsche Gesellschaft für Palliativmedizin e.V.) without any influence on the content of the recommendations.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethics

The consortium study was approved by the Ethics Committee of the Faculty of Medicine, FAU Erlangen: 302_13 B, 15.01.2014 and the Institutional Review Board Regensburg and by the appointed data protection officers. Participating patients, family caregivers and staff members provided written informed consent.

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Maria Heckel
    • 1
  • Stephanie Stiel
    • 2
  • Franziska A. Herbst
    • 2
  • Johanna M. Tiedtke
    • 3
  • Alexander Sturm
    • 5
  • Thomas Adelhardt
    • 6
  • Christian Bogdan
    • 4
  • Cornel Sieber
    • 5
  • Oliver Schöffski
    • 6
  • Frieder R. Lang
    • 3
  • Christoph Ostgathe
    • 1
  1. 1.Department of Palliative MedicineUniversitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenGermany
  2. 2.Institute for General Practice, Hannover Medical SchoolHannoverGermany
  3. 3.Institute of PsychogerontologyFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)NürnbergGermany
  4. 4.Institute of Clinical Microbiology, Immunology, and HygieneUniversitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenGermany
  5. 5.Department of General Internal and Geriatric Medicine, Krankenhaus Barmherzige Brüder (Hospital of the Order of St. John of God Regensburg), Institute for Biomedicine of AgingFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)RegensburgGermany
  6. 6.Division of Health Management, School of Business and EconomicsInstitute of Management (IFM) Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)NürnbergGermany

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