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Supportive Care in Cancer

, Volume 26, Issue 7, pp 2239–2246 | Cite as

Health-related quality of life and pelvic floor dysfunction in advanced-stage ovarian cancer survivors: associations with objective activity behaviors and physiological characteristics

  • Christelle Schofield
  • Robert U. Newton
  • Paul A. Cohen
  • Daniel A. Galvão
  • Joanne A. McVeigh
  • Ganendra R. Mohan
  • Jason Tan
  • Stuart G. Salfinger
  • Leon M. Straker
  • Carolyn J. Peddle-McIntyre
Original Article

Abstract

Purpose

Little is known about the relationship between health-related quality of life (HRQoL), pelvic floor dysfunction (PFD), and modifiable lifestyle and physiological factors for ovarian cancer survivors (OCS). The primary aim of the study was to compare post-treatment advanced-stage OCS with age-matched controls on measures of HRQoL and PFD. The secondary aim was to examine associations between HRQoL, PFD, objective activity behaviors, physical function, and body composition in OCS.

Methods

Twenty advanced-stage OCS and 20 controls completed questionnaires assessing HRQoL (SF-36) and PFD (Australian Pelvic Floor Questionnaire), and underwent objective assessments of activity behavior (7-day accelerometry), physical function (400-m walk, repeated chair rise, 6-m usual-pace walk, one-repetition maximum chest press, and single-leg extension), and body composition (dual-energy x-ray absorptiometry).

Results

Compared to controls, OCS had worse physical HRQoL (− 4.3 median difference, p = 0.013), but equivalent self-reported PFD, indicated by combined bladder, bowel, and pelvic organ prolapse symptoms (0.89 mean difference, p = 0.277). In OCS, physical HRQoL was significantly negatively associated with PFD (r = 0.468, p = 0.043). Decreased physical HRQoL and increased PFD were significantly associated with less moderate-to-vigorous physical activity in ≥ 10-min bouts (ρ = 0.627, p = 0.003; ρ = − 0.457, p = 0.049), more sedentary time (r = − 0.449, p = 0.047; r = 0.479, p = 0.038), and slower 400-m walk time (ρ = − 0.565, p = 0.022; ρ = 0.504, p = 0.028).

Conclusions

Post-treatment advanced-stage OCS have decreased physical HRQoL, which is associated with modifiable factors such as worse PFD, less moderate-to-vigorous physical activity, more sedentary time, and decreased objective physical function. This highlights the need for ongoing supportive care and multidisciplinary interventions after first-line ovarian cancer treatment.

Keywords

Ovarian cancer Health-related quality of life Pelvic floor dysfunction Moderate-to-vigorous physical activity (MVPA) Sedentary time 

Notes

Funding information

Dr. Paul A. Cohen receives salary support from the Jakovich Family and the St John of God Foundation.

Prof Daniel A. Galvão is supported by a Cancer Council of Western Australia Research Fellowship.

Dr. Carolyn J. Peddle-McIntyre is supported by a Cancer Council of Western Australia Postdoctoral Research Fellowship.

Compliance with ethical standards

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Christelle Schofield
    • 1
  • Robert U. Newton
    • 1
    • 2
  • Paul A. Cohen
    • 3
    • 4
    • 5
  • Daniel A. Galvão
    • 1
  • Joanne A. McVeigh
    • 6
    • 7
  • Ganendra R. Mohan
    • 3
    • 4
    • 8
    • 9
  • Jason Tan
    • 3
    • 4
    • 8
    • 10
  • Stuart G. Salfinger
    • 3
    • 4
    • 8
    • 11
  • Leon M. Straker
    • 12
  • Carolyn J. Peddle-McIntyre
    • 1
  1. 1.Exercise Medicine Research InstituteEdith Cowan UniversityJoondalupAustralia
  2. 2.UQ Centre for Clinical ResearchUniversity of QueenslandHerstonAustralia
  3. 3.St John of God Hospital Bendat Family Comprehensive Cancer CentreSubiacoAustralia
  4. 4.Division of Women’s and Infants’ Health, School of MedicineUniversity of Western AustraliaCrawleyAustralia
  5. 5.Institute for Health ResearchUniversity of Notre Dame AustraliaFremantleAustralia
  6. 6.School of Occupational Therapy and Social WorkCurtin UniversityBentleyAustralia
  7. 7.Exercise Laboratory, School of PhysiologyUniversity of WitwatersrandJohannesburgSouth Africa
  8. 8.School of MedicineUniversity of Notre Dame AustraliaFremantleAustralia
  9. 9.NedlandsAustralia
  10. 10.WOMEN CentreWest LeedervilleAustralia
  11. 11.St John of God HospitalSubiacoAustralia
  12. 12.School of Physiotherapy and Exercise ScienceCurtin UniversityBentleyAustralia

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