How to report adherence to treatment as clinically relevant data—making a case of CML and TKI
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Adherence comes from the Latin word “adhaerere”, and implies to “remain constant”, to “keep close” or to “maintain” . When this concept is brought to therapeutics, such as patients with chronic myeloid leukemia (CML) using tyrosine kinase inhibitors (TKI), the persistence of an individual to adhering to treatment is somehow simplified to self-referred and non-validated questionnaires .
Despite the interesting article from Moulin et al. about the role of clinical pharmacists on CML, which is one of the first from Latin America, adherence to TKI needs to evolve from over past concepts, such as simply dichotomizing adherence . More consistent, practice-oriented and reproducible adherence methods are the keys to providing external and internal validation in CML studies . This report aims to discuss how to address adherence to treatment as clinically relevant outcome, making a case of TKI and CML.
By taking a good example of HIV medications, one adherence tool (medication...
The author was given a monthly scholarship from the Brazilian Ministry of Education, by the time the letter was conceived (Residência Integrada Multiprofissional em Saúde).
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Conflict of interest
The author declares that there are no conflicts of interest.