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Supportive Care in Cancer

, Volume 25, Issue 11, pp 3529–3536 | Cite as

The impact of breast cancer treatments on sleep quality 1 year after cancer diagnosis

  • Filipa Fontes
  • Susana Pereira
  • Ana Rute Costa
  • Marta Gonçalves
  • Nuno LunetEmail author
Original Article

Abstract

Purpose

The increasing number of women living longer with potential side effects of breast cancer treatment highlights the need of a comprehensive assessment of its burden. Therefore, we aimed to quantify the relation between different breast cancer treatments and sleep quality 1 year after diagnosis.

Methods

A cohort of 502 newly diagnosed breast cancer patients was prospectively followed. Sleep quality was evaluated with the Pittsburgh Sleep Quality Index (PSQI), at baseline and at the 1-year follow-up. Odds ratios (OR) were computed to quantify the association between patient characteristics and poor sleep quality (PSQI score >5) at baseline, and relative risks (RR) were computed for the association between treatments and the occurrence of poor sleep quality at 1 year.

Results

A total of 60.2% of the patients had poor sleep quality before breast cancer treatments, especially those with anxiety [OR = 2.86, 95% confidence interval (95%CI) 1.92 to 4.27] or depression (OR = 5.25, 95%CI 2.01 to 13.67). Radiotherapy increased the risk of poor sleep quality at 1 year (RR = 3.71, 95%CI 1.15 to 11.96, for a cumulative dose >50 Gy) and there was a tendency for a higher risk in those submitted to chemotherapy, although not statistically significant.

Conclusions

Our study shows that sleep disturbances are frequent before cancer treatment and confirms their co-occurrence with other medical conditions, such as anxiety and depression. Different breast cancer treatments increase the risk of impaired sleep quality, therefore contributing to the global disability associated with cancer treatments.

Keywords

Antineoplastic protocols Breast cancer Quality of life Radiotherapy Sleep 

Notes

Compliance with ethical standards

Funding

FF and ARC have received co-funded by the “Fundação para a Ciência e a Tecnologia” and the POPH/FSE Program (grant numbers SFRH/BD/92630/2013 and SFRH/BD/102181/2014, respectively). Data management activities were supported by the Chair on Pain Medicine of the Faculty of Medicine, University of Porto and by the Grünenthal Foundation – Portugal.

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The study was approved by the Ethics Committee of the Portuguese Institute of Oncology of Porto (Ref. CES 406/011) and by the Portuguese Data Protection Authority (Ref. 9469/2012). All participants provided written informed consent.

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Filipa Fontes
    • 1
  • Susana Pereira
    • 1
    • 2
  • Ana Rute Costa
    • 1
  • Marta Gonçalves
    • 1
    • 3
  • Nuno Lunet
    • 1
    • 4
    Email author
  1. 1.ISPUP-EPIUnitUniversity of PortoPortoPortugal
  2. 2.Portuguese Institute of Oncology of PortoPortoPortugal
  3. 3.Sleep Medicine Center - CUF Porto HospitalPortoPortugal
  4. 4.Department of Clinical Epidemiology, Predictive Medicine and Public Health, Faculty of MedicineUniversity of PortoPortoPortugal

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