Supportive Care in Cancer

, Volume 25, Issue 6, pp 2009–2017 | Cite as

Development of depression in survivors of childhood and adolescent cancer: a multi-level life course conceptual framework

  • Erica C. Kaye
  • Tara M. Brinkman
  • Justin N. Baker
Review Article
First Online:
Received:
Accepted:

Abstract

As therapeutic and supportive care interventions become increasingly effective, growing numbers of childhood and adolescent cancer survivors face a myriad of physical and psychological sequelae secondary to their disease and treatment. Mental health issues, in particular, present a significant problem in this unique patient population, with depression affecting a sizable number of childhood and adolescent cancer survivors. Multiple key determinants impact a survivor’s risk of developing depression, with variables traversing across biologic, individual, family, community, and global levels, as well as spanning throughout the life course of human development from the preconception and prenatal periods to adulthood. A multi-level life course conceptual model offers a valuable framework to identify and organize the diverse variables that modulate the risk of developing depression in survivors of childhood and adolescent cancer. This review describes the first multi-level life course perspective applied to development of depression in childhood and adolescent cancer survivors. This conceptual framework may be used to guide the investigation of mental health interventions for SCACs to ensure that key determinants of depression occurrence are adequately addressed across various levels and throughout the life trajectory.

Keywords

Pediatric Cancer survivor Depression Multi-level Life course Conceptual framework 
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Notes

Compliance with ethical standards

Financial disclosures

There are no financial disclosures from the authors on this manuscript.

Conflicts of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Erica C. Kaye
    • 1
  • Tara M. Brinkman
    • 2
  • Justin N. Baker
    • 1
    • 3
  1. 1.Department of OncologySt. Jude Children’s Research HospitalMemphisUSA
  2. 2.Department of Epidemiology and Cancer ControlSt. Jude Children’s Research HospitalMemphisUSA
  3. 3.Division of Quality of Life and Palliative CareSt. Jude Children’s Research HospitalMemphisUSA

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