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Supportive Care in Cancer

, Volume 25, Issue 5, pp 1579–1586 | Cite as

Clinical research participation among adolescent and young adults at an NCI-designated Comprehensive Cancer Center and affiliated pediatric hospital

  • Stacy D. Sanford
  • Jennifer L. Beaumont
  • Mallory A. Snyder
  • Jennifer Reichek
  • John M. Salsman
Original Article

Abstract

Purpose

Minimal clinical trial participation among adolescents and young adults (AYAs) with cancer limits scientific progress and ultimately their clinical care and outcomes. These analyses examine the current state of AYA clinical research participation at a Midwestern comprehensive cancer center and affiliated pediatric hospital to advise program development and increase availability of trials and AYA participation. Enrollment is examined across all diagnoses, the entire AYA age spectrum (15–39), and both cancer therapeutic and supportive care protocols.

Methods

his study was a retrospective review of electronic medical records via existing databases and registries for all AYAs. Data were collected for AYAs seen by an oncologist at the adult outpatient cancer center or at the pediatric hospital between the years 2010 and 2014. Descriptive statistics and logistic regression analyses were conducted to characterize this sample.

Results

In the pediatric setting, 42.3% of AYAs were enrolled in a study compared to 11.2% in the adult setting. Regression analyses in the pediatric setting revealed that AYAs with private insurance or Caucasian race were more likely to participate. Within the adult setting, ethnicity, race, insurance, and diagnosis were associated with study participation; 54.8% of study enrollments were for cancer therapeutic and 43.4% for supportive care studies.

Conclusions

These results are comparable to previously published data and support the need for new local and national AYA initiatives to increase the availability of and enrollment in therapeutic clinical trials. The same is true for supportive care studies which play a crucial role in improving quality of life.

Keywords

Adolescents Young adults Clinical trials Cancer survivors 

Notes

Compliance with ethical standards

Conflict of interest

There are no financial disclosures from the authors. This work was unfunded and there are no conflicts of interest. The authors have full control of all primary data and agree to allow review of the data upon request.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Stacy D. Sanford
    • 1
    • 2
  • Jennifer L. Beaumont
    • 1
  • Mallory A. Snyder
    • 1
  • Jennifer Reichek
    • 1
    • 3
  • John M. Salsman
    • 4
  1. 1.Northwestern University Feinberg School of MedicineChicagoUSA
  2. 2.Robert H. Lurie Comprehensive Cancer Center of Northwestern UniversityChicagoUSA
  3. 3.Ann and Robert H. Lurie Children’s Hospital of ChicagoChicagoUSA
  4. 4.Wake Forest School of MedicineWinston-SalemUSA

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