Supportive Care in Cancer

, Volume 24, Issue 6, pp 2627–2634 | Cite as

Helplessness/hopelessness, minimization and optimism predict survival in women with invasive ovarian cancer: a role for targeted support during initial treatment decision-making?

  • Melanie A. Price
  • Phyllis N. Butow
  • Melanie L. Bell
  • Anna deFazio
  • Michael Friedlander
  • Joanna E. Fardell
  • Melinda M. Protani
  • Penelope M. Webb
  • AOCS—Quality of Life Study Investigators on behalf of the Australian Ovarian Cancer Study Group
Original Article

Abstract

Purpose

Women with advanced ovarian cancer generally have a poor prognosis but there is significant variability in survival despite similar disease characteristics and treatment regimens. The aim of this study was to determine whether psychosocial factors predict survival in women with ovarian cancer, controlling for potential confounders.

Methods

The sample comprised 798 women with invasive ovarian cancer recruited into the Australian Ovarian Cancer Study and a subsequent quality of life study. Validated measures of depression, optimism, minimization, helplessness/hopelessness, and social support were completed 3–6 monthly for up to 2 years. Four hundred nineteen women (52.5 %) died over the follow-up period. Associations between time-varying psychosocial variables and survival were tested using adjusted Cox proportional hazard models.

Results

There was a significant interaction of psychosocial variables measured prior to first progression and overall survival, with higher optimism (adjusted hazard ratio per 1 standard deviation (HR) = 0.80, 95 % confidence interval (CI) 0.65–0.97), higher minimization (HR = 0.79, CI 0.66–0.94), and lower helplessness/hopelessness (HR = 1.40, CI 1.15–1.71) associated with longer survival. After disease progression, these variables were not associated with survival (optimism HR = 1.10, CI 0.95–1.27; minimization HR = 1.12, CI 0.95–1.31; and helplessness/hopelessness HR = 0.86, CI 0.74–1.00). Depression and social support were not associated with survival.

Conclusions

In women with invasive ovarian cancer, psychosocial variables prior to disease progression appear to impact on overall survival, suggesting a preventive rather than modifying role. Addressing psychosocial responses to cancer and their potential impact on treatment decision-making early in the disease trajectory may benefit survival and quality of life.

Keywords

Ovarian cancer Oncology Psychological factors Survival Predictors 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Melanie A. Price
    • 1
    • 2
  • Phyllis N. Butow
    • 1
    • 2
  • Melanie L. Bell
    • 2
    • 3
  • Anna deFazio
    • 4
  • Michael Friedlander
    • 5
    • 6
  • Joanna E. Fardell
    • 2
  • Melinda M. Protani
    • 7
  • Penelope M. Webb
    • 7
  • AOCS—Quality of Life Study Investigators on behalf of the Australian Ovarian Cancer Study Group
    • 1
    • 2
    • 4
    • 7
  1. 1.Centre for Medical Psychology and Evidence-based Decision-making (CeMPED), School of PsychologyThe University of SydneySydneyAustralia
  2. 2.Psycho-oncology Co-operative Research Group (PoCoG)The University of SydneySydneyAustralia
  3. 3.Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public HealthUniversity of ArizonaTucsonUSA
  4. 4.Department of Gynaecological Oncology, Westmead Hospital and Westmead Institute for Cancer ResearchThe University of Sydney at Westmead Millennium InstituteWestmeadAustralia
  5. 5.Prince of Wales Clinical SchoolUniversity of New South WalesSydneyAustralia
  6. 6.Department of Medical OncologyPrince of Wales HospitalRandwickAustralia
  7. 7.Gynaecological Cancers GroupQIMR Berghofer Medical Research InstituteBrisbaneAustralia

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